1 ANBAS Corporation, 4-12-10 Toyosaki, Kita-ku, Osaka 531-0072, Japan.
2 Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Benef Microbes. 2019 Apr 19;10(3):293-300. doi: 10.3920/BM2018.0083. Epub 2019 Jan 14.
Various lactobacilli have been suggested to exert beneficial effects in humans. In this study, we examined the effects of intraduodenal (ID) administration of heat-killed LAB4 (LAB4) on activities of efferent sympathetic nerves innervating the liver and pancreas. Consequently, it was observed that ID administration of LAB4 significantly reduced either the efferent hepatic sympathetic nerve activity (hepatic-SNA) or pancreatic sympathetic nerve activity (pancreatic-SNA) in urethane-anaesthetised rats. Moreover, the effect of acute and chronic administration of LAB4 (1×10 cells/ml) on hyperglycaemia induced by intracranial injection of 2-deoxy-D-glucose (2DG) were examined in conscious rats. We found that LAB4 significantly inhibited 2DG-induced hyperglycaemia. These findings suggest that ID administration of heat-killed LAB4 might lower plasma glucose level via changes in the autonomic nervous system in rats.
各种乳酸菌已被证明对人类有益。在这项研究中，我们研究了十二指肠内（ID）给予热灭活 LAB4（LAB4）对支配肝脏和胰腺的传出交感神经活动的影响。结果表明，ID 给予 LAB4 可显著降低乌拉坦麻醉大鼠的肝传出交感神经活动（肝-SNA）或胰腺传出交感神经活动（胰腺-SNA）。此外，还在清醒大鼠中研究了急性和慢性给予 LAB4（1×10 个细胞/ml）对颅内注射 2-脱氧-D-葡萄糖（2DG）引起的高血糖的影响。我们发现 LAB4 可显著抑制 2DG 诱导的高血糖。这些发现表明，ID 给予热灭活 LAB4 可能通过改变大鼠自主神经系统来降低血浆葡萄糖水平。
