a Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences , Ghent University , Ghent , Belgium.
b Ghent Research Group on Nanomedicines , Ghent University , Ghent , Belgium.
Curr Eye Res. 2019 May;44(5):465-475. doi: 10.1080/02713683.2019.1565890. Epub 2019 Jan 30.
The inner limiting membrane (ILM) represents the structural boundary between the vitreous and the retina, and is suggested to act as a barrier for a wide range of retinal therapies. While it is widely acknowledged that the morphology of the human ILM exhibits regional variations and undergoes age-related changes, insight into its structure in laboratory animals is very limited. Besides presenting a detailed overview of the morphology and composition of the human ILM, this review specifically reflects on the species-specific differences in ILM structure. With these differences in mind, we furthermore summarize the most relevant reports on the barrier role of the ILM with regard to viral vectors, nanoparticles, anti-VEGF medication and stem cells. Overall, this review aims to deliberate on the impact of species-specific ILM variations on drug delivery research as well as to pinpoint knowledge gaps which future basic research should resolve.
内界膜（ILM）代表玻璃体和视网膜之间的结构边界，被认为是多种视网膜治疗方法的屏障。虽然人们普遍认为人类 ILM 的形态存在区域性差异，并随年龄发生变化，但对实验室动物的 ILM 结构的了解非常有限。除了详细概述人类 ILM 的形态和组成外，本综述还特别反映了 ILM 结构的种间特异性差异。考虑到这些差异，我们还总结了关于 ILM 对病毒载体、纳米颗粒、抗 VEGF 药物和干细胞的屏障作用的最相关报告。总的来说，本综述旨在讨论种间特异性 ILM 变化对药物输送研究的影响，并指出未来基础研究应解决的知识空白。
