Applied Neuroscience Research Group, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic; Department of Radiology and Nuclear Medicine, University Hospital Brno, Faculty of Medicine, Brno, Czech Republic.
Applied Neuroscience Research Group, Central European Institute of Technology, CEITEC MU, Masaryk University, Brno, Czech Republic.
Int Rev Neurobiol. 2019;144:95-141. doi: 10.1016/bs.irn.2018.10.005. Epub 2018 Nov 28.
Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Although diagnosis may be challenging, there is increasing evidence that the use of biomarkers according to 2017 revised criteria for diagnosis and management of dementia with Lewy bodies can increase diagnostic accuracy. Apart from nuclear medicine techniques, various magnetic resonance imaging (MRI) techniques have been utilized in attempt to enhance diagnostic accuracy. This chapter reviews structural, functional and diffusion MRI studies in DLB cohorts being compared to healthy controls, AD or dementia in Parkinson's disease (PDD). We also included relatively new MRI methods that may have potential to identify early DLB subjects and aim at examining brain iron and neuromelanin.
路易体痴呆（DLB）是仅次于阿尔茨海默病（AD）的第二大常见神经退行性痴呆病因。虽然诊断可能具有挑战性，但越来越多的证据表明，根据 2017 年修订的路易体痴呆诊断和管理标准使用生物标志物可以提高诊断准确性。除核医学技术外，还尝试使用各种磁共振成像（MRI）技术来提高诊断准确性。本章综述了结构、功能和弥散 MRI 研究在 DLB 队列中与健康对照、AD 或帕金森病痴呆（PDD）的比较。我们还包括了一些可能有潜力识别早期 DLB 受试者的相对较新的 MRI 方法，并旨在检查脑铁和神经黑色素。
