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Belimumab reduces antiphospholipid antibodies in SLE patients independently of hydroxychloroquine treatment.

作者信息

Emmi Giacomo, Bettiol Alessandra, Palterer Boaz, Silvestri Elena, Vitiello Gianfranco, Parronchi Paola, Prisco Domenico

机构信息

Department of Experimental and Clinical Medicine, University of Firenze, Italy.

Department of Experimental and Clinical Medicine, University of Firenze, Italy; Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Firenze, Italy.

出版信息

Autoimmun Rev. 2019 Mar;18(3):312-314. doi: 10.1016/j.autrev.2018.11.002. Epub 2019 Jan 11.

DOI:10.1016/j.autrev.2018.11.002
PMID:30639638
Abstract
摘要

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Belimumab reduces antiphospholipid antibodies in SLE patients independently of hydroxychloroquine treatment.贝利尤单抗可降低系统性红斑狼疮患者的抗磷脂抗体水平，与羟氯喹治疗无关。
Autoimmun Rev. 2019 Mar;18(3):312-314. doi: 10.1016/j.autrev.2018.11.002. Epub 2019 Jan 11.
2
Association of subcutaneous belimumab and long-term antimalarial treatment reduces antiphospholipid antibodies levels in systemic lupus erythematosus: post-hoc analysis of a randomised placebo-controlled trial-comment on: 'Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus' by Chatzidionysiou .皮下注射贝利尤单抗与长期抗疟治疗联合应用可降低系统性红斑狼疮患者的抗磷脂抗体水平：一项随机安慰剂对照试验的事后分析——对Chatzidionysiou的“贝利尤单抗治疗对抗磷脂抗体水平的影响：基于两项系统性红斑狼疮随机安慰剂对照试验的事后分析”的评论
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Anticardiolipin and anti-beta 2 glycoprotein-I antibodies disappearance in patients with systemic lupus erythematosus and antiphospholipid syndrome while on belimumab.系统性红斑狼疮和抗磷脂综合征患者在使用贝利尤单抗治疗期间抗心磷脂抗体和抗β2糖蛋白-I抗体消失的情况。
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Hydroxychloroquine as an anti-thrombotic in antiphospholipid syndrome.羟氯喹在抗磷脂综合征中的抗血栓作用。
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Response to: 'Association of subcutaneous belimumab and long-term antimalarial treatment reduces antiphospholipid antibodies levels in systemic lupus erythematosus: post-hoc analysis of a randomised placebo-controlled trial-comment on: 'Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus' by Chatzidionysiou ' by Bettiol .对以下内容的回应：“皮下注射贝利尤单抗与长期抗疟治疗联合使用可降低系统性红斑狼疮患者的抗磷脂抗体水平：一项随机安慰剂对照试验的事后分析——评Chatzidionysiou等人的‘贝利尤单抗治疗对抗磷脂抗体水平的影响：基于两项系统性红斑狼疮随机安慰剂对照试验的事后分析’”，作者为Bettiol 。
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New onset of lupus nephritis in two patients with SLE shortly after initiation of treatment with belimumab.两名系统性红斑狼疮（SLE）患者在开始使用贝利尤单抗治疗后不久出现了狼疮性肾炎。
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Clinical manifestations of the antiphospholipid syndrome in patients with systemic lupus erythematosus associate more strongly with anti-beta 2-glycoprotein-I than with antiphospholipid antibodies.系统性红斑狼疮患者抗磷脂综合征的临床表现与抗β2糖蛋白I的关联比与抗磷脂抗体的关联更强。
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Clin Rheumatol. 2025 May 3. doi: 10.1007/s10067-025-07411-1.
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Successful management of belimumab after obinutuzumab in a patient with systemic lupus erythematosus: a case report with an 18-month follow-up.成功管理系统性红斑狼疮患者奥滨尤妥珠单抗治疗后的贝利尤单抗：附 18 个月随访的病例报告。
Front Immunol. 2024 Oct 3;15:1459241. doi: 10.3389/fimmu.2024.1459241. eCollection 2024.
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抗磷脂综合征的免疫抑制治疗：是否值得？
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16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.第十六届抗磷脂抗体国际大会抗磷脂综合征治疗趋势工作组报告。
Lupus. 2020 Oct;29(12):1571-1593. doi: 10.1177/0961203320950461.
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Is there a role for immunosuppression in antiphospholipid syndrome?抗磷脂综合征中免疫抑制的作用如何？
Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):426-432. doi: 10.1182/hematology.2019000073.