Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Curr Opin Pharmacol. 2019 Jun;46:14-18. doi: 10.1016/j.coph.2018.12.001. Epub 2019 Jan 11.
Rosacea is a common inflammatory skin disease that is difficult to manage because of the unknown etiology and due to its variable manifestations. These facts and the few new available treatment options make it difficult to select a really effective treatment. This review aims to assess the efficacy and safety of novel treatment options for rosacea. The topical alpha adrenergic agonist oxymetazoline reduces rosacea-related erythema. Topical ivermectin improves lesion count, inflammation, and maintenance of remission of rosacea compared to topical metronidazole. Procedural therapies including pulsed dye laser, radiofrequency, and dual frequency ultrasound are promising as both monotherapies or in combination. Although there are several effective treatment modalities for rosacea management, treatments options should be tailored for the specific clinical scenario.
酒渣鼻是一种常见的炎症性皮肤疾病，由于病因不明，临床表现多样，因此难以治疗。这些事实和少数新的治疗选择使得很难选择一种真正有效的治疗方法。本综述旨在评估酒渣鼻新型治疗选择的疗效和安全性。局部 α 肾上腺素能激动剂奥洛他定可减轻酒渣鼻相关的红斑。与局部甲硝唑相比，局部伊维菌素可改善病变计数、炎症和酒渣鼻缓解的维持。包括脉冲染料激光、射频和双频超声在内的程序治疗方法有希望作为单一疗法或联合疗法。尽管有几种有效的酒渣鼻治疗方法，但治疗方案应根据具体的临床情况进行调整。
