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酒渣鼻治疗进展

Update on the management of rosacea.

作者信息

Weinkle Allison P, Doktor Vladyslava, Emer Jason

机构信息

School of Medicine, University of California San Diego, La Jolla, CA, USA.

Dermatology Department, St John's Episcopal Hospital, Queens, NY, USA.

出版信息

Clin Cosmet Investig Dermatol. 2015 Apr 7;8:159-77. doi: 10.2147/CCID.S58940. eCollection 2015.

Abstract

Refining diagnostic criteria has identified key characteristics differentiating rosacea, a chronic skin disorder, from other common cutaneous inflammatory conditions. The current classification system developed by the National Rosacea Society Expert Committee consists of erythematotelangiectatic, papulopustular, phymatous, and ocular subtypes. Each subtype stands as a unique entity among a spectrum, with characteristic symptoms and physical findings, along with an intricate pathophysiology. The main treatment modalities for rosacea include topical, systemic, laser, and light therapies. Topical brimonidine tartrate gel and calcineurin inhibitors are at the forefront of topical therapies, alone or in combination with traditional therapies such as topical metronidazole or azelaic acid and oral tetracyclines or isotretinoin. Vascular laser and intense pulsed light therapies are beneficial for the erythema and telangiectasia, as well as the symptoms (itching, burning, pain, stinging, swelling) of rosacea. Injectable botulinum toxin, topical ivermectin, and microsecond long-pulsed neodymium-yttrium aluminum garnet laser are emerging therapies that may prove to be extremely beneficial in the future. Once a debilitating disorder, rosacea has become a well known and manageable entity in the setting of numerous emerging therapeutic options. Herein, we describe the treatments currently available and give our opinions regarding emerging and combination therapies.

摘要

完善诊断标准已明确了区分玫瑰痤疮(一种慢性皮肤疾病)与其他常见皮肤炎症性疾病的关键特征。美国国家玫瑰痤疮协会专家委员会制定的现行分类系统包括红斑毛细血管扩张型、丘疹脓疱型、鼻赘型和眼型亚型。每种亚型在一系列症状中都是独特的个体,具有特征性症状和体格检查结果,以及复杂的病理生理学。玫瑰痤疮的主要治疗方式包括局部治疗、全身治疗、激光治疗和光疗。酒石酸溴莫尼定凝胶和钙调神经磷酸酶抑制剂是局部治疗的前沿药物,可单独使用或与传统治疗药物如局部用甲硝唑或壬二酸以及口服四环素或异维A酸联合使用。血管激光和强脉冲光治疗对玫瑰痤疮的红斑、毛细血管扩张以及症状(瘙痒、灼痛、疼痛、刺痛、肿胀)有益。注射用肉毒杆菌毒素、局部用伊维菌素和微秒长脉冲钕钇铝石榴石激光是新兴治疗方法,未来可能被证明极具益处。玫瑰痤疮曾经是一种使人衰弱的疾病,在众多新兴治疗选择的背景下,它已成为一种广为人知且可控制的疾病。在此,我们描述了目前可用的治疗方法,并给出了我们对新兴治疗方法和联合治疗方法的看法。

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