Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510230, China.
Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou 510095, China.
Seizure. 2019 Feb;65:80-88. doi: 10.1016/j.seizure.2019.01.004. Epub 2019 Jan 10.
Sexual functioning is an important factor influencing quality of life. Mounting evidence suggests that both male and female patients with epilepsy (PWE) have an increased risk of developing sexual dysfunction (SD). The aim of this meta-analysis was to quantify the association between epilepsy and the risk of SD.
PubMed, Embase, and Cochrane Library database were systematically searched to identify the pertinent studies focusing on the association between epilepsy and SD. Relative risk (RR) for SD with 95% confidence interval (CI) was calculated. The overall quality of the evidence was generated by applying the GRADE-profiler. This meta-analysis was registered on the PROSPERO (ID: CRD42018103572, http://www.crd.york.ac.uk/PROSPERO).
Nine studies (3 cross-sectional, 5 case-control, and 1 cohort) were included in this meta-analysis, for a total of 1556 subjects and 599 cases of epilepsy. Synthetic results demonstrated that epilepsy was associated with an increased risk of female SD (6 studies, pooled RR = 2.69, 95%CI: 1.48-4.89, P = 0.001; heterogeneity: I = 88.9%, P < 0.001) as well as male SD (3 studies, pooled RR = 4.85, 95%CI: 2.01-11.7, P < 0.001; heterogeneity: I = 74.2%, P = 0.021). The GRADE-profiler showed that the rate of events of SD on average in the PWE and the controls were 383/659 (58.1%) and 168/1017 (16.5%), respectively. The quality of evidence across outcomes was MODERATE.
Epilepsy is significantly associated with an increased risk of SD in both sexes. These findings suggest that both clinicians and patients should recognize that epilepsy has a potential hazardous effect on sexual functioning.
性功能是影响生活质量的一个重要因素。越来越多的证据表明，男性和女性癫痫患者（PWE）发生性功能障碍（SD）的风险增加。本荟萃分析的目的是量化癫痫与 SD 风险之间的关系。
系统检索 PubMed、Embase 和 Cochrane 图书馆数据库，以确定关注癫痫与 SD 之间关联的相关研究。使用 95%置信区间（CI）计算 SD 的相对风险（RR）。应用 GRADE-profiler 生成整体证据质量。本荟萃分析已在 PROSPERO（ID：CRD42018103572，http://www.crd.york.ac.uk/PROSPERO）上注册。
本荟萃分析纳入了 9 项研究（3 项横断面研究、5 项病例对照研究和 1 项队列研究），共纳入 1556 名受试者和 599 例癫痫患者。综合结果表明，癫痫与女性 SD（6 项研究，汇总 RR=2.69，95%CI：1.48-4.89，P=0.001；异质性：I=88.9%，P<0.001）以及男性 SD（3 项研究，汇总 RR=4.85，95%CI：2.01-11.7，P<0.001；异质性：I=74.2%，P=0.021）的风险增加相关。GRADE-profiler 显示，PWE 和对照组的 SD 事件发生率平均分别为 383/659（58.1%）和 168/1017（16.5%）。所有结局的证据质量为中等级别。
癫痫与两性 SD 风险增加显著相关。这些发现表明，临床医生和患者都应该认识到癫痫对性功能有潜在的危害作用。
