Department of Urology and Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Department of Reproduction, Southern Medical University Affiliate Dongguan People's Hospital, Dongguan, China.
J Sex Med. 2019 Mar;16(3):434-446. doi: 10.1016/j.jsxm.2018.12.017. Epub 2019 Feb 14.
Mounting evidence has emerged suggesting that patients with Parkinson's disease (PD) are susceptible to sexual dysfunction (SD).
To better clarify the relationship between PD and SD.
PubMed, Embase, Cochrane Library database, and PsychINFO database were systematically searched for pertinent studies evaluating sexual function in the patients with PD. This systematic review and meta-analysis have been registered on PROSPERO (ID: CRD42018108714; http://www.crd.york.ac.uk/PROSPERO).
The association between PD and SD was assessed using relative risk (RR) with 95% CI. The quality of evidence was ranked by the GRADE profiler.
11 observational studies met the predefined criteria for inclusion, enrolling 30,150 subjects from both the PD group and healthy control group (mean age 54.6-75.1 years). Synthesis results revealed that PD was associated with an elevated risk of SD in males (7 studies; 1.79; 95% CI = 1.26-2.54, P = .001; heterogeneity: I = 73.2%, P < .001). However, when restricted to female subjects, the combined RR from 3 eligible studies suggested a lack of significant association between PD and SD (RR = 1.3, 95% CI = 0.64-2.61, P = .469; heterogeneity: I = 80.0%, P = .007). The GRADE profiler indicated the overall quality of the evidence was low in studies including males and very low in studies including females.
The current meta-analysis indicated that men with PD were more likely to experience SD than those without PD. In female subjects, however, PD seemed to not be associated with a high prevalence of SD compared with healthy controls. Based on these findings, patients with PD should be routinely assessed for sexual functioning, especially males.
STRENGTHS & LIMITATIONS: This is the first systematic review and meta-analysis of the association between PD and the risks of SD in both males and females. However, substantial heterogeneities were detected across the included studies.
A hazardous effect of PD for developing SD was detected in men but not in women. As a result, sexual function assessment and appropriate therapy are recommended for men with PD in clinical practice. Zhao S, Wang J, Xie Q, et al. Parkinson's Disease Is Associated with Risk of Sexual Dysfunction in Men but Not in Women: A Systematic Review and Meta-Analysis J Sex Med 2019;16:434-446.
越来越多的证据表明帕金森病（PD）患者易发生性功能障碍（SD）。
更好地阐明 PD 与 SD 之间的关系。
系统检索 PubMed、Embase、Cochrane 图书馆数据库和 PsychINFO 数据库中评估 PD 患者性功能的相关研究。本系统评价和荟萃分析已在 PROSPERO（ID：CRD42018108714；http://www.crd.york.ac.uk/PROSPERO）上注册。
纳入的 11 项观察性研究符合纳入标准，共纳入 30150 名来自 PD 组和健康对照组的受试者（平均年龄 54.6-75.1 岁）。使用 95%CI 的相对风险（RR）评估 PD 与 SD 之间的关联。使用 GRADE 分析员对证据质量进行了分级。
PD 与男性发生 SD 的风险增加相关，但与女性发生 SD 的风险无关。因此，建议在临床实践中对男性 PD 患者进行性功能评估和适当的治疗。
