Graduate Program in Physical Education and Health, Catholic University of Brasília, Taguatinga-DF, Brazil.
Department of Physical Education, UDF University Center, Brasilia-DF, Brazil.
J Strength Cond Res. 2021 Jun 1;35(6):1693-1699. doi: 10.1519/JSC.0000000000002932.
Aguiar, SS, Rosa, TS, Sousa, CV, Santos, PA, Barbosa, LP, Deus, LA, Rosa, EC, Andrade, RV, and Simões, HG. Influence of body fat on oxidative stress and telomere length of master athletes. J Strength Cond Res 35(6): 1693-1699, 2021-The present investigation analyzed the role of body fat and training history on biological aging of master athletes by comparing and verifying the relationships between markers of adiposity, oxidative balance, and telomere length (TL) in middle-aged runners and untrained individuals. Master athletes (sprinters and endurance runners, n = 21; 51.62 ± 8.19 years) and untrained age-matched controls (n = 11; 45.41 ± 10.34 years) had blood samples collected for biochemical and biomolecular analyzes. Pro-oxidant and antioxidant measures as well as DNA extraction were performed using commercial kits. Relative TL (T/S) was determined in leukocytes through quantitative polymerase chain reaction analyses. Master athletes had lower body fat and longer TL than untrained controls (body fat: 12.21 ± 4.14% vs. 26.03 ± 4.29%; TL: 1.10 ± 0.84 vs. 0.56 ± 0.56 T/S; p < 0.05). Furthermore, master athletes also showed a better oxidative balance than untrained controls (p < 0.05). A negative correlation was observed between TL and body fat (r = -0.471; p = 0.007), and conicity index (r = -0.407; p = 0.021), catalase activity (r = -0.569; p = 0.001), and CAT/TBARS ratio (r = -0.463; p = 0.008) for the whole sample. In conclusion, master athletes have longer TL, better oxidative profile, and lower body fat than untrained individuals. Moreover, for this middle-aged sample, body fat was inversely correlated with both TL and markers of oxidative balance, demonstrating the key role of adiposity in biological aging.
阿吉亚尔，SS，罗莎，TS，索萨，CV，桑托斯，PA，巴博萨，LP，德乌斯，LA，罗莎，EC，安德拉德，RV，和席尔瓦，HG。体脂对优秀运动员氧化应激和端粒长度的影响。J 力量与调节研究 35（6）：1693-1699，2021-本研究通过比较和验证中年跑步者和未训练个体的肥胖标志物、氧化平衡和端粒长度（TL）之间的关系，分析了体脂和训练史对优秀运动员生物衰老的作用。优秀运动员（短跑和耐力跑运动员，n=21；51.62±8.19 岁）和年龄匹配的未训练对照组（n=11；45.41±10.34 岁）采集血液样本进行生化和生物分子分析。使用商业试剂盒进行促氧化剂和抗氧化剂测量以及 DNA 提取。通过定量聚合酶链反应分析在白细胞中确定相对 TL（T/S）。优秀运动员的体脂和 TL 均低于未训练对照组（体脂：12.21±4.14%对 26.03±4.29%；TL：1.10±0.84 对 0.56±0.56 T/S；p<0.05）。此外，优秀运动员的氧化平衡也优于未训练对照组（p<0.05）。TL 与体脂（r=-0.471；p=0.007）和锥形指数（r=-0.407；p=0.021）、过氧化氢酶活性（r=-0.569；p=0.001）和 CAT/TBARS 比值（r=-0.463；p=0.008）呈负相关，整个样本。总之，优秀运动员的 TL 较长，氧化谱较好，体脂较少，未训练个体。此外，对于这个中年样本，体脂与 TL 和氧化平衡标志物呈负相关，表明肥胖在生物衰老中起着关键作用。
