IEEE Trans Biomed Eng. 2019 Sep;66(9):2596-2603. doi: 10.1109/TBME.2019.2892407. Epub 2019 Jan 11.
The aim of the study was to show if pulse rise times (PRTs) extracted from photoplethysmographic (PPG) pulse waves (PWs) have an association with peripheral arterial disease (PAD) or its endovascular treatment, percutanoeus transluminal angioplasty (PTA) of the superficial femoral artery.
Lower and upper limb PPG PWs were recorded and analyzed from 24 patients who suffered from PAD. The measurements were conducted before and after the treatment, and one month later by using transmission-mode PPG-probes placed in the index finger and second toe. Ankle-to-brachial pressure index and toe pressures were used as references in clinical patient measurements. PRTs, i.e., the time from the foot point to the peak point of the PW, were extracted from the PWs and compared bilaterally. The results from the PAD patients were also compared with 31 same-aged and 34 younger control subjects.
Statistically significant differences were found between the pretreatment PRTs of the treated limb of the PAD patients and the same-aged control subjects ( , Mann-Whitney U-test). The changes in the PRT of the treated lower limb were observed immediately after the PTA ( , Student's t-test), and after one month ( ), whereas the PRTs of the non-treated lower limb and upper limb did not indicate changes between different examinations.
Results show that a PRT greater than 240 ms indicates PAD-lesions in the lower limb.
This proof-of-concept study suggests that the PRT could be an effective and easy-to-use indicator for PAD and monitoring the effectiveness of its treatment.
本研究旨在展示从光电容积脉搏波（PPG）脉搏波（PW）中提取的脉搏上升时间（PRT）是否与外周动脉疾病（PAD）或其血管内治疗，经皮腔内血管成形术（PTA）的股浅动脉有关。
从患有 PAD 的 24 名患者中记录和分析了下肢和上肢的 PPG PPG。在治疗前后以及一个月后，使用放置在食指和第二趾的传输模式 PPG 探头进行了测量。踝肱压指数和趾压用作临床患者测量的参考。从 PW 中提取 PRT，即从足部到 PW 峰值的时间，并在双侧进行比较。还将 PAD 患者的结果与 31 名同龄和 34 名年轻对照组进行了比较。
PAD 患者治疗肢体的预处理 PRT 与同龄对照组之间存在统计学显著差异（ ，Mann-Whitney U 检验）。在 PTA 后立即观察到治疗下肢的 PRT 变化（ ，Student's t 检验），一个月后（ ），而未治疗的下肢和上肢的 PRT 没有表明不同检查之间的变化。
结果表明，PRT 大于 240ms 表明下肢 PAD 病变。
这项概念验证研究表明，PRT 可能是 PAD 及其治疗效果监测的有效且易于使用的指标。
