Department of Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Department of Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
Int J Gynecol Cancer. 2019 Jan;29(1):17-22. doi: 10.1136/ijgc-2018-000025.
We investigated whether the pretreatment albumin to globulin ratio, serum albumin level, and serum globulin level can be used to predict survival among cervical cancer patients treated with radiation based therapy and assessed globulin fractions.
We retrospectively enrolled 128 patients with cervical cancer treated with radiation based therapy at our institution between 2010 and 2015. The associations of the pretreatment albumin to globulin ratio, and serum albumin and globulin levels with overall survival were assessed. Additionally, the associations of the globulin fractions with the serum globulin levels and overall survival were evaluated.
Median follow-up duration was 30 months (IQR 16-44 months). A low albumin to globulin ratio (< 1.53) was found to be an independent prognostic factor for overall survival (HR= 3.07; 95% CI, 1.03 to 13.3; P=0.044). On evaluating serum globulin and albumin separately, a high serum globulin level was significantly associated with overall survival (cut-off value 2.9 g/dL; HR=3.74; 95% CI 1.08 to 23.6; P=0.036) whereas a low serum albumin level was not associated with overall survival (cut-off value 3.6 g/dL; HR=1.77; 95% CI 0.57 to 4.54; P=0.29). Electrophoresis data of the serum proteins revealed that the γ-globulin fraction was most strongly correlated with the globulin levels (P<0.001). Furthermore, a high γ-globulin level (≥1.28 g/dL) was significantly associated with poor overall survival (log rank test, P=0.034).
A pretreatment low albumin to globulin ratio, which might be attributable to a high serum globulin level, can be used to predict poor prognosis in cervical cancer patients treated with radiation based therapy.
我们研究了治疗宫颈癌的放射治疗患者的预处理白蛋白与球蛋白比值、血清白蛋白和球蛋白水平能否用于预测生存情况，并评估球蛋白各成分。
我们回顾性纳入了 2010 年至 2015 年在我院接受放射治疗的 128 例宫颈癌患者。评估了预处理白蛋白与球蛋白比值、血清白蛋白和球蛋白水平与总生存率之间的相关性。此外，还评估了球蛋白各成分与血清球蛋白水平和总生存率之间的相关性。
中位随访时间为 30 个月（IQR 16-44 个月）。低白蛋白与球蛋白比值（<1.53）是总生存率的独立预后因素（HR=3.07；95%CI，1.03-13.3；P=0.044）。单独评估血清球蛋白和白蛋白时，高血清球蛋白水平与总生存率显著相关（截断值 2.9g/dL；HR=3.74；95%CI 1.08-23.6；P=0.036），而低血清白蛋白水平与总生存率无关（截断值 3.6g/dL；HR=1.77；95%CI 0.57-4.54；P=0.29）。血清蛋白电泳数据显示，γ-球蛋白成分与球蛋白水平相关性最强（P<0.001）。此外，高γ-球蛋白水平（≥1.28g/dL）与总生存率差显著相关（对数秩检验，P=0.034）。
治疗宫颈癌的放射治疗患者的预处理白蛋白与球蛋白比值较低，可能归因于血清球蛋白水平较高，可用于预测预后不良。
