Pan Chi, Gu Yawen, Ni Qingtao
Department of General Surgery, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, People's Republic of China.
Department of Oncology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, 225300, People's Republic of China.
Breast Cancer (Dove Med Press). 2024 Jul 25;16:403-411. doi: 10.2147/BCTT.S471747. eCollection 2024.
This study examined the potential risk value of the serum albumin to globulin ratio (AGR) in patients with breast cancer (BC).
This study employed a retrospective design, enrolling 332 patients with BC and 38 patients without BC treated at Taizhou People's Hospital between September 2015 and May 2021. Multivariate Cox proportional hazard regression models were used to identify potential risk factors. A prognostic nomogram was developed based on the multivariate analyses. The receiver operating characteristic curve determined the optimal cutoff value for AGR.
The results indicated a statistically significant decrease in AGR among patients with BC. Significant disparities were observed in globulin and AGR levels between the two cohorts. AGR was significantly associated with tumor size and stage, with a marked decline in advanced stages of BC. Additionally, AGR and aspartate transaminase/Alanine aminotransferase (AST/ALT) emerged as significant diagnostic indicators for invasive carcinoma and advanced stages (II-IV) of BC. Specifically, AGR exhibited an area under the curve of 0.645 (P < 0.003), highlighting the discriminatory capacity of serum globulin levels in distinguishing between BC and non-BC cohorts.
The AGR, routinely assessed due to its simplicity, objectivity, and cost-effectiveness, holds promise as a potential risk factor for BC and may have practical implications in clinical settings.
本研究探讨血清白蛋白与球蛋白比值（AGR）在乳腺癌（BC）患者中的潜在风险价值。
本研究采用回顾性设计，纳入了2015年9月至2021年5月在泰州市人民医院接受治疗的332例BC患者和38例非BC患者。使用多变量Cox比例风险回归模型来识别潜在风险因素。基于多变量分析绘制了预后列线图。通过受试者工作特征曲线确定AGR的最佳临界值。
结果表明，BC患者的AGR在统计学上显著降低。两组患者的球蛋白和AGR水平存在显著差异。AGR与肿瘤大小和分期显著相关，在BC晚期显著下降。此外，AGR和天冬氨酸转氨酶/丙氨酸转氨酶（AST/ALT）是浸润性癌和BC晚期（II-IV期）的重要诊断指标。具体而言，AGR的曲线下面积为0.645（P<0.003），突出了血清球蛋白水平在区分BC和非BC队列中的鉴别能力。
AGR因其简单、客观和成本效益而被常规评估，有望成为BC的潜在风险因素，并可能在临床环境中具有实际意义。
