Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, PPGBM-UFRGS, Porto Alegre, Rio Grande do Sul, Brazil.
Laboratório de Medicina Genômica, Serviço de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, LMG-SPE-HCPA, Porto Alegre, Rio Grande do Sul, Brazil.
PLoS One. 2019 Jan 14;14(1):e0210762. doi: 10.1371/journal.pone.0210762. eCollection 2019.
Colorectal cancer (CRC) is the second most common cancer in women and the third most common cancer in men globally. The identification of differentially expressed genes associated to patient's clinical data may represent a useful approach to find important genes in CRC carcinogenesis. Previously, the TULP3 transcription factor was identified as a possible prognostic biomarker in pancreatic ductal adenocarcinoma. Considering that pancreatic and colorectal tissues have the same embryonic origin, we investigated the profile of TULP3 expression in CRC hypothesizing that it may have a role in its development. We comparatively analysed TULP3 gene expression in CRC and normal adjacent colonic tissue and assessed association of expression profiles with survival and clinicopathological information, using publicly available datasets. TULP3 expression levels were increased in CRC when compared to the adjacent non-tumoral tissue. In addition, higher TULP3 gene expression was associated to lymphatic and vascular invasion in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ), respectively. In summary, our results point to a possible role of TULP3 as a diagnostic and prognostic biomarker in CRC. Additional studies are necessary to confirm these preliminary findings.
结直肠癌（CRC）是全球女性中第二常见的癌症，也是男性中第三常见的癌症。鉴定与患者临床数据相关的差异表达基因可能是发现 CRC 发生发展中重要基因的一种有用方法。先前，TULP3 转录因子被鉴定为胰腺导管腺癌的一种可能的预后生物标志物。鉴于胰腺和结直肠组织具有相同的胚胎起源，我们假设 TULP3 可能在 CRC 发生发展中发挥作用，对其在 CRC 中的表达谱进行了研究。我们使用公开数据集比较分析了 CRC 和正常相邻结肠组织中 TULP3 基因的表达，并评估了表达谱与生存和临床病理信息的关联。与相邻非肿瘤组织相比，CRC 中的 TULP3 表达水平增加。此外，较高的 TULP3 基因表达与结肠腺癌（COAD）和直肠腺癌（READ）中的淋巴和血管浸润分别相关。总之，我们的结果表明 TULP3 可能作为 CRC 的诊断和预后生物标志物发挥作用。需要进一步的研究来证实这些初步发现。
