Department of Ophthalmology, Medical School, University of Thessaly, Larissa, Greece.
Neonatal Intensive Care Unit, University Hospital of Larissa, Larissa, Greece.
Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):98-106. doi: 10.1167/iovs.18-24776.
The purpose of this study was to prospectively investigate the association between retinopathy of prematurity (ROP) and ocular growth in premature infants during the earliest weeks of life.
Premature infants in the national ROP screening program were recruited and examined at 1- or 2-week intervals between 30 and 38 weeks of postmenstrual age. One hundred infants with gestational age (GA) between 24 and 35 weeks (30.04 + 2.13), and birth weight (BW) between 550 and 2060 g (1251.45 + 317.19) were included in the study. At each examination, the presence, stage, and zone of ROP were recorded along with axial length (AL), central corneal thickness (CCT), and weight gain. Biometric parameters were measured by A-scan biometry. Study variables included GA, BW, AL, CCT, weight gain, relative weight (RW), and dif_AL, dif_CCT, and dif_weight, which are the differences between two consecutive recordings of the same infant. Multiple regression analysis models were used to determine the association between the study variables and ROP.
dif_AL, dif_CCT, and RW were the most appropriate variables to detect the optimal threshold points that discriminate ROP: weekly increase of AL < 0.095 mm, weekly reduction of CCT < 0.5 μm, or weekly weight gain < 7% is associated with ROP development.
ROP is associated with delayed ocular development, as eyes of premature infants with ROP have shorter axial lengths and thicker corneas than eyes of premature infants without ROP. The association of AL, CCT, and weight gain with ROP could be of value for future development of predictive models for ROP.
本研究旨在前瞻性研究早产儿视网膜病变（ROP）与出生后最早几周内早产儿眼部生长的关系。
在全国ROP 筛查计划中招募早产儿，并在胎龄（GA）为 30 至 38 周之间的 1 至 2 周间隔进行检查。该研究纳入了 100 名 GA 在 24 至 35 周之间（30.04+2.13）、BW 在 550 至 2060 克之间（1251.45+317.19）的婴儿。在每次检查中，记录 ROP 的存在、分期和区域，以及眼轴长度（AL）、中央角膜厚度（CCT）和体重增加。生物测量参数通过 A 型超声生物测量法测量。研究变量包括 GA、BW、AL、CCT、体重增加、相对体重（RW）以及 dif_AL、dif_CCT 和 dif_weight，它们是同一婴儿两次连续记录之间的差异。采用多元回归分析模型来确定研究变量与 ROP 之间的关系。
dif_AL、dif_CCT 和 RW 是检测最佳阈值点的最适当变量，这些阈值点可以区分 ROP：AL 每周增加<0.095mm、CCT 每周减少<0.5μm 或每周体重增加<7%与 ROP 发展相关。
ROP 与眼部发育迟缓有关，因为患有 ROP 的早产儿的眼轴长度较短，角膜较厚，而没有 ROP 的早产儿的眼轴长度较长，角膜较薄。AL、CCT 和体重增加与 ROP 的相关性可能对未来 ROP 预测模型的发展具有价值。
