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从血管内皮生长因子在精子发生中的作用探讨中医“精血同源”理论

[Explanation of 'Essence and Blood from the Same Source' in Theory of Chinese Medicine from the Roles of Vascular Endothelial Growth Factor in Spermatogenesis].

作者信息

Sun Da-Lin, Jin Bao-Fang

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Oct;36(10):1261-1264.

PMID:30641017
Abstract

'Essence and blood from the same source', as one of basic theories of Chinese medi- cine (CM), is important for syndrome typing and clinical medication. Vascular endothelial growth factor (VEGF) can be produced and secreted in Leydig cells and Sertoli cells, which can not only promote the formation of new blood vessels, but also regulate synthesis of testosterone and the proliferation and dif- ferentiation of germ cells. The roles of VEGF in the spermatogenesis reveal scientific connotations of 'essence and blood from the same source', and it plays an important role in guiding clinical practice of CM.

摘要

“精血同源”作为中医基础理论之一,对辨证分型和临床用药具有重要意义。血管内皮生长因子(VEGF)可在睾丸间质细胞和支持细胞中产生并分泌,它不仅能促进新血管形成,还能调节睾酮合成以及生殖细胞的增殖与分化。VEGF在精子发生过程中的作用揭示了“精血同源”的科学内涵,对指导中医临床实践具有重要意义。

相似文献

1
[Explanation of 'Essence and Blood from the Same Source' in Theory of Chinese Medicine from the Roles of Vascular Endothelial Growth Factor in Spermatogenesis].从血管内皮生长因子在精子发生中的作用探讨中医“精血同源”理论
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Oct;36(10):1261-1264.
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Expression of vascular endothelial growth factor receptors during male germ cell differentiation in the mouse.小鼠雄性生殖细胞分化过程中血管内皮生长因子受体的表达
Biol Reprod. 2003 Sep;69(3):985-94. doi: 10.1095/biolreprod.102.013581. Epub 2003 May 28.
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Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement.利用睾丸间质细胞破坏和睾酮替代研究精子发生控制中的细胞间相互作用。
Am J Anat. 1990 May;188(1):3-20. doi: 10.1002/aja.1001880103.
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Vascular endothelial growth factor A is a putative paracrine regulator in seasonally controlled spermatogenesis: insights from a ruminant model, the roe deer.血管内皮生长因子A是季节性控制精子发生过程中一种假定的旁分泌调节因子:来自反刍动物模型狍的见解。
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[Studies on expression and location of VEGF protein in rat testis and epididymis].[大鼠睾丸和附睾中血管内皮生长因子蛋白表达及定位的研究]
Shi Yan Sheng Wu Xue Bao. 2004 Feb;37(1):1-8.
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Paracrine role of Sertoli cells.支持细胞的旁分泌作用。
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Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage VI-VIII seminiferous tubules from adult rats.睾酮与精子发生:雄激素调节成年大鼠 VI - VIII 期生精小管细胞分泌机制的证据。
J Androl. 1995 Nov-Dec;16(6):499-509.
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Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells.缺氧对小鼠TM3 Leydig细胞中血管内皮生长因子和睾酮释放的影响。
Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1763-9. doi: 10.1152/ajpendo.00611.2006. Epub 2007 Mar 20.
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Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone.促黄体生成素受体介导的对促性腺激素缺乏(hpg)小鼠精子发生起始的影响可被睾酮复制。
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Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis.雄激素受体在大鼠睾丸中的分布:雄激素对精子发生调节的新启示。
Endocrinology. 1994 May;134(5):2307-16. doi: 10.1210/endo.134.5.8156934.

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