Nathwani B N, Brynes R K
Department of Pathology, University of Southern California, School of Medicine, Los Angeles 90033.
Semin Diagn Pathol. 1988 Nov;5(4):317-28.
The purpose of this report is to emphasize the criteria for recognizing the benign diseases such as viral lymphadenitis, necrotizing lymphadenitis, cat scratch disease, etc, in which a proliferation of immunoblasts is evident, and to discuss the criteria for distinguishing these diseases from neoplastic and atypical proliferations of immunoblasts. In this report, we use the term "immunoblasts" for transformed lymphoid cells of medium and large size. These cells may or may not have abundant quantities of cytoplasm, which may or may not be deeply staining. These immunoblasts may be of the B or the T cell type, and they may be mononuclear, binucleated, or multinucleated. The distinction between benign and malignant immunoblastic proliferations is not made on the basis of cytologic features, but by assessment of all histologic parameters including the architectural pattern, the cellular composition of the proliferation, the relationship of different cell types to one another, and the cytologic features of the immunoblasts.
本报告的目的是强调识别良性疾病（如病毒感染性淋巴结炎、坏死性淋巴结炎、猫抓病等）的标准，这些疾病中免疫母细胞明显增殖，并讨论将这些疾病与免疫母细胞的肿瘤性和非典型增殖相区分的标准。在本报告中，我们使用“免疫母细胞”一词来指代中等大小和大尺寸的转化淋巴细胞。这些细胞可能有也可能没有丰富的细胞质，细胞质可能深染也可能不深染。这些免疫母细胞可能是B细胞型或T细胞型，可能是单核、双核或多核。良性和恶性免疫母细胞增殖的区分不是基于细胞学特征，而是通过评估所有组织学参数，包括结构模式、增殖的细胞组成、不同细胞类型之间的关系以及免疫母细胞的细胞学特征来进行的。
