Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Endodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Mar;127(3):210-217. doi: 10.1016/j.oooo.2018.11.006. Epub 2018 Nov 24.
Cytokines have regulatory and leading roles in the immunopathogenesis of oral lichen planus (OLP). Here, we present the findings of a meta-analysis that evaluated serum and salivary interferon-γ (IFN-γ) levels in patients with OLP compared with those in controls and the correlation of this cytokine with the progression of OLP.
Four databases-PubMed, Web of Science, Scopus, and Cochrane Library-were searched, from their start dates to November 2017, for reports in all languages on the effect of OLP on salivary and serum IFN-γ.
Eleven studies were included and analyzed in this meta-analysis. The pooled mean difference (MD) values were estimated to be 3.60 pg/mL (P = .23) and -0.02 pg/mL (P = 1.00) for serum and salivary levels of IFN-γ, respectively, in the patients with OLP compared with controls. The pooled MD values were -2.52 pg/mL (P = .03) and -2.01 pg/mL (P = .20) for serum and salivary IFN-γ levels in the erosive type, respectively, compared with the nonerosive type.
According to the results of meta-analysis, there was no statistically significant differences in IFN-γ levels between the OLP group and the control group both in serum and salivary levels and also between erosive and nonerosive types of OLP at the salivary level; so this cytokine is not considered to have an important role in the pathogenesis or severity of OLP.
细胞因子在口腔扁平苔藓（OLP）的免疫发病机制中具有调节和主导作用。在这里，我们进行了一项荟萃分析，评估了与对照组相比，OLP 患者的血清和唾液干扰素-γ（IFN-γ）水平，并分析了该细胞因子与 OLP 进展的相关性。
从各数据库的起始日期到 2017 年 11 月，我们检索了所有语言的报告，以评估 OLP 对唾液和血清 IFN-γ的影响，所检索的数据库包括 PubMed、Web of Science、Scopus 和 Cochrane Library。
本荟萃分析纳入了 11 项研究。与对照组相比，OLP 患者的血清 IFN-γ水平的合并均数差（MD）值估计为 3.60 pg/mL（P=0.23），唾液 IFN-γ水平的 MD 值为-0.02 pg/mL（P=1.00）。与非糜烂型相比，糜烂型 OLP 患者的血清 IFN-γ水平的 MD 值分别为-2.52 pg/mL（P=0.03）和-2.01 pg/mL（P=0.20），唾液 IFN-γ水平的 MD 值分别为-2.52 pg/mL（P=0.03）和-2.01 pg/mL（P=0.20）。
根据荟萃分析的结果，OLP 组与对照组在血清和唾液水平以及糜烂型和非糜烂型 OLP 患者的唾液 IFN-γ水平之间，IFN-γ 水平均无统计学差异，因此该细胞因子在 OLP 的发病机制或严重程度中不被认为具有重要作用。
