狼疮患者接受不同肾脏替代治疗的长期结局。
Long-term outcomes in lupus patients receiving different renal replacement therapy.
机构信息
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Program in Translational and Interdisciplinary Medicine, Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
出版信息
J Microbiol Immunol Infect. 2019 Aug;52(4):648-653. doi: 10.1016/j.jmii.2018.12.010. Epub 2019 Jan 4.
BACKGROUND/PURPOSE: To compare the long-term outcomes and survival rates of patients with end stage renal disease (ESRD) caused by lupus nephritis who received three different modalities of renal replacement therapy, including hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT).
METHODS
We retrospectively analyzed 94 patients with ESRD caused by lupus nephritis. Among these, 42 received HD, 12 received PD, and 40 underwent KT. The adverse events, survival data and cause of mortality were recorded.
RESULTS
The mean age at onset of ESRD was younger in the KT group than in the HD group. Arteriovenous fistula (AVF) infection, sepsis, and AVF dysfunction were more common in the HD group than in the KT group. Peritonitis was more common in the PD group than in the HD group and KT group. Urinary tract infection was more common in the KT group than in the HD group. Cumulative survival rates were better in the KT group than in the HD or PD group.
CONCLUSION
The patients with ESRD caused by lupus nephritis who underwent KT had better long-term outcomes and survival rates than those who received HD or PD. This implies that KT is the better choice of renal replacement therapy in the patients with ESRD caused by lupus nephritis.
背景/目的：比较狼疮性肾炎终末期肾病（ESRD）患者接受三种不同肾脏替代治疗方式（血液透析（HD）、腹膜透析（PD）和肾移植（KT））的长期结果和生存率。
方法
我们回顾性分析了 94 例狼疮性肾炎引起的 ESRD 患者。其中，42 例接受 HD，12 例接受 PD，40 例接受 KT。记录不良事件、生存数据和死亡原因。
结果
KT 组 ESRD 发病时的平均年龄小于 HD 组。HD 组的动静脉瘘（AVF）感染、败血症和 AVF 功能障碍比 KT 组更常见。PD 组的腹膜炎比 HD 组和 KT 组更常见。HD 组的尿路感染比 KT 组更常见。KT 组的累积生存率优于 HD 组或 PD 组。
结论
与接受 HD 或 PD 治疗的患者相比，接受 KT 的狼疮性肾炎 ESRD 患者具有更好的长期结果和生存率。这表明在狼疮性肾炎引起的 ESRD 患者中，KT 是更好的肾脏替代治疗选择。
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