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No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.不留死角：导管内乳头状黏液性肿瘤的异质性。
Clin Cancer Res. 2019 Apr 1;25(7):2027-2029. doi: 10.1158/1078-0432.CCR-18-3877. Epub 2019 Jan 14.
2
Disease spectrum of intraductal papillary mucinous neoplasm with an associated invasive carcinoma invasive IPMN versus pancreatic ductal adenocarcinoma-associated IPMN.伴有浸润性癌的导管内乳头状黏液性肿瘤与胰腺导管腺癌相关的导管内乳头状黏液性肿瘤的疾病谱：浸润性 IPMN 与胰腺导管腺癌相关的 IPMN。
Pancreas. 2013 Nov;42(8):1267-74. doi: 10.1097/mpa.0b013e3182954137.
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Evaluation of SOX9 expression in pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm.评估胰腺导管腺癌和导管内乳头状黏液性肿瘤中 SOX9 的表达。
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A commentary on the article: "Intraductal papillary mucinous carcinoma versus pancreatic ductal adenocarcinoma: A systematic review and meta-analysis", Int J Surg 2019;71:91-99.对文章《导管内乳头状黏液性癌与胰腺导管腺癌：系统评价与荟萃分析》的述评，《国际外科学杂志》2019年；第71卷：91 - 99页
Int J Surg. 2019 Nov;71:170-171. doi: 10.1016/j.ijsu.2019.10.003. Epub 2019 Oct 9.
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Inferior head resection of the pancreas for intraductal papillary mucinous neoplasms.胰腺内导管乳头状黏液性肿瘤的胰头下切除术。
J Hepatobiliary Pancreat Sci. 2010 Nov;17(6):798-802. doi: 10.1007/s00534-009-0173-8. Epub 2009 Aug 29.
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Intraductal Papillary Mucinous Neoplasm of the Pancreas as the Main Focus for Early Detection of Pancreatic Adenocarcinoma.胰腺导管内乳头状黏液性肿瘤作为早期检测胰腺腺癌的主要关注点。
Pancreas. 2018 May/Jun;47(5):544-550. doi: 10.1097/MPA.0000000000001047.
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Pancreatic resection for intraductal papillary mucinous neoplasm- a thirteen-year single center experience.导管内乳头状黏液性肿瘤的胰腺切除术——单中心13年经验
BMC Cancer. 2016 Nov 4;16(1):844. doi: 10.1186/s12885-016-2887-8.
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Molecular mechanism of intraductal papillary mucinous neoplasm and intraductal papillary mucinous neoplasm-derived pancreatic ductal adenocarcinoma.导管内乳头状黏液性肿瘤及导管内乳头状黏液性肿瘤衍生的胰腺导管腺癌的分子机制
J Hepatobiliary Pancreat Sci. 2015 Jul;22(7):519-23. doi: 10.1002/jhbp.246. Epub 2015 Apr 21.
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Intraductal papillary mucinous neoplasm.导管内乳头状黏液性肿瘤。
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Targeted DNA Sequencing Reveals Patterns of Local Progression in the Pancreatic Remnant Following Resection of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas.靶向DNA测序揭示胰腺导管内乳头状黏液性肿瘤（IPMN）切除术后胰腺残余局部进展模式。
Ann Surg. 2017 Jul;266(1):133-141. doi: 10.1097/SLA.0000000000001817.

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Clinical and Molecular Attributes and Evaluation of Pancreatic Cystic Neoplasm.临床和分子特征与胰腺囊性肿瘤评估。
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Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception.在导管内乳头状黏液性肿瘤的组织学进展过程中，免疫监视减弱，为癌症阻断提供了治疗机会。
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Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models.胰腺导管内乳头状黏液性肿瘤：其遗传特征与小鼠模型综述
Cancers (Basel). 2021 Oct 22;13(21):5296. doi: 10.3390/cancers13215296.
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Symphony in chaos: Immune orchestra during pancreatic cancer progression.混乱中的交响乐：胰腺癌进展过程中的免疫乐团
EBioMedicine. 2020 Jun;56:102787. doi: 10.1016/j.ebiom.2020.102787. Epub 2020 May 23.
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Observation or resection of pancreatic intraductal papillary mucinous neoplasm: An ongoing tug of war.胰腺导管内乳头状黏液性肿瘤的观察或切除：一场持续的拉锯战。
World J Gastrointest Oncol. 2019 Dec 15;11(12):1092-1100. doi: 10.4251/wjgo.v11.i12.1092.

本文引用的文献

1
Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.单细胞转录组学分析胰腺癌前体，显示上皮和微环境异质性是肿瘤进展早期的事件。
Clin Cancer Res. 2019 Apr 1;25(7):2194-2205. doi: 10.1158/1078-0432.CCR-18-1955. Epub 2018 Nov 1.
2
Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer.调节性T细胞与肿瘤相关树突状细胞之间的串扰削弱了胰腺癌的抗肿瘤免疫。
Cell Rep. 2017 Jul 18;20(3):558-571. doi: 10.1016/j.celrep.2017.06.062.
3
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.胰腺癌中不同的炎性成纤维细胞和肌成纤维细胞群体。
J Exp Med. 2017 Mar 6;214(3):579-596. doi: 10.1084/jem.20162024. Epub 2017 Feb 23.
4
γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation.γδ T细胞通过抑制αβ T细胞活化来支持胰腺癌发生。
Cell. 2016 Sep 8;166(6):1485-1499.e15. doi: 10.1016/j.cell.2016.07.046. Epub 2016 Aug 25.
5
Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.单细胞RNA测序可识别胰腺循环肿瘤细胞的细胞外基质基因表达。
Cell Rep. 2014 Sep 25;8(6):1905-1918. doi: 10.1016/j.celrep.2014.08.029. Epub 2014 Sep 18.

不留死角：导管内乳头状黏液性肿瘤的异质性。

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.

机构信息

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

Massachusetts General Hospital Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts.

出版信息

Clin Cancer Res. 2019 Apr 1;25(7):2027-2029. doi: 10.1158/1078-0432.CCR-18-3877. Epub 2019 Jan 14.

DOI:10.1158/1078-0432.CCR-18-3877
PMID:30642914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6445728/
Abstract

Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer..

摘要

导管内乳头状黏液性肿瘤（IPMN）是一种具有明确遗传特征的胰腺癌前病变，但这些肿瘤的细胞生态系统仍有待全面描述。本研究利用单细胞 RNA 测序描述了上皮细胞、免疫细胞和基质细胞在 IPMN 进展为浸润性癌过程中的动态景观。