Small Scott A, Swanson Larry W
Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Department of Neurology, Columbia University, New York, New York 10027, USA.
Department of Biological Sciences, University of Southern California, Los Angeles, California 90007, USA.
Cold Spring Harb Symp Quant Biol. 2018;83:193-200. doi: 10.1101/sqb.2018.83.036889. Epub 2019 Jan 14.
Studies in patients and mouse models have pinpointed a precise zone in the cerebral cortex selectively vulnerable to the earliest stages of Alzheimer's disease (AD): the borderzone covering the entorhinal and perirhinal cortical areas. An independent series of studies has revealed that this entorhinal-perirhinal borderzone is a central cortical hub, with a distinct connectivity pattern across the cerebral hemispheres. Here we develop a hypothesis that explains how this distinct network feature interacts with established pathogenic drivers of AD in explaining the disease's regional vulnerability and suggests how it acts as an anatomical source of disease spread.
针对患者和小鼠模型的研究已经确定了大脑皮层中一个在阿尔茨海默病（AD）最早阶段选择性易损的精确区域：覆盖内嗅皮质和嗅周皮质区域的边界区。一系列独立研究表明，这个内嗅 - 嗅周边界区是一个中央皮质枢纽，在大脑半球间具有独特的连接模式。在此，我们提出一个假说，解释这种独特的网络特征如何与已确定的AD致病驱动因素相互作用，以解释该疾病的区域易损性，并说明它如何作为疾病传播的解剖学源头。
