Murakami Tomoaki, Miyoshi Tomoyuki, Takahashi Natsumi, Kangawa Akihisa
Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Swine and Poultry Research Center, Shizuoka Prefectural Research Institute of Animal Industry, 2780 Nishikata, Kikugawa-shi, Shizuoka 439-0037, Japan.
J Vet Med Sci. 2019 Mar 14;81(3):357-360. doi: 10.1292/jvms.18-0321. Epub 2019 Jan 15.
Two Large Yorkshire piglets were diagnosed as persistent hyperplastic primary vitreous (PHPV). In case 1, the white cord-like structure extending from optic disc to lens was observed in the normal-sized right eye. Case 2 showed buphthalmos of the right eye. The internal structure of the right eye was unclear due to bleeding, but a white cord-like structure was slightly observed. In both cases, histological examinations revealed the fibrovascular cord-like structure in hyaloid vitreous. The retina was detached, and dysplastic nervous tissue was observed in anterior vitreous. Immunohistochemistry using various neural markers suggested that dysplastic nervous tissue was derived from the detached neural retina. By the characteristic macroscopic and histopathological features, both cases were diagnosed as PHPV. To our knowledge, this is the first report of swine PHPV.
两头大约克夏仔猪被诊断为持续性增生性原发性玻璃体（PHPV）。病例1中，在正常大小的右眼观察到从视盘延伸至晶状体的白色条索状结构。病例2表现为右眼巩膜葡萄肿。由于出血，右眼内部结构不清，但隐约可见白色条索状结构。在这两个病例中，组织学检查均显示透明玻璃体中有纤维血管条索状结构。视网膜脱离，在前玻璃体中观察到发育异常的神经组织。使用各种神经标志物的免疫组织化学分析表明，发育异常的神经组织源自脱离的神经视网膜。根据特征性的大体和组织病理学特征，这两个病例均被诊断为PHPV。据我们所知，这是猪PHPV的首例报告。
