黏菌素与多种抗菌药物联合对[具体物种]的体外活性：来自伊朗南部的一份报告
In vitro activity of colistin in combination with various antimicrobials against species, a report from South Iran.
作者信息
Kheshti Raziyeh, Pourabbas Bahman, Mosayebi Maryam, Vazin Afsaneh
机构信息
Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran,
Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran,
出版信息
Infect Drug Resist. 2018 Dec 31;12:129-135. doi: 10.2147/IDR.S182585. eCollection 2019.
Abstract
INTRODUCTION
is a gram-negative,opportunistic pathogen responsible for resistant nosocomial infections especially in the intensive care units (ICUS).One reason for the failure in the treatment of is its ability of develop resistance against several antimicrobials. combination of different antimicrobials can be used to overcome such a resistance. This study was done to evaluate the in vitro synergistic activity of colistin in combination with six different antimicrobials, including ciprofloxacin, levofloxacin, imipenem, meropenem, ampicillin-sulbactam, and rifampin against species isolated from blood culture of patients admitted to ICUs of Nemazee hospital, Shiraz, Iran.
METHOD
After performing biochemical identification assays on 20 isolates of , minimum inhibitory concentrations were determined by E- test method and antibiotic interactions were assessed using broth microdilution checkerboard method.
RESULTS
Combinations of colistin with all six studied antimicrobials had some synergistic effect.
CONCLUSION
clinical studies are required to clarify the therapeutic potential of these antimicrobial combinations.
摘要
引言
[病原体名称]是一种革兰氏阴性机会致病菌，可导致耐药性医院感染，尤其是在重症监护病房（ICU）。其治疗失败的一个原因是它能够对多种抗菌药物产生耐药性。不同抗菌药物联合使用可克服这种耐药性。本研究旨在评估黏菌素与六种不同抗菌药物（环丙沙星、左氧氟沙星、亚胺培南、美罗培南、氨苄西林-舒巴坦和利福平）联合对从伊朗设拉子内马齐医院ICU患者血培养中分离出的[病原体名称]菌株的体外协同活性。
方法
对20株[病原体名称]进行生化鉴定试验后，采用E-test法测定最低抑菌浓度，并使用肉汤微量稀释棋盘法评估抗生素相互作用。
结果
黏菌素与所有六种研究的抗菌药物联合均有一定的协同作用。
结论
需要进行临床研究以阐明这些抗菌药物联合的治疗潜力。
相似文献
1
In vitro activity of colistin in combination with various antimicrobials against species, a report from South Iran.黏菌素与多种抗菌药物联合对[具体物种]的体外活性：来自伊朗南部的一份报告
Infect Drug Resist. 2018 Dec 31;12:129-135. doi: 10.2147/IDR.S182585. eCollection 2019.
2
[In vitro synergistic activity of sulbactam in combination with imipenem, meropenem and cefoperazone against carbapenem-resistant Acinetobacter baumannii isolates].舒巴坦与亚胺培南、美罗培南和头孢哌酮联合对耐碳青霉烯类鲍曼不动杆菌分离株的体外协同活性
Mikrobiyol Bul. 2014 Apr;48(2):311-5. doi: 10.5578/mb.7104.
3
In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii.替加环素与多种抗菌药物联合对多重耐药鲍曼不动杆菌的体外活性
Ann Clin Microbiol Antimicrob. 2009 May 21;8:18. doi: 10.1186/1476-0711-8-18.
4
In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units.非传统抗菌药物单独或联合使用对从重症监护病房分离出的多重耐药铜绿假单胞菌和鲍曼不动杆菌菌株的体外活性。
Int J Antimicrob Agents. 2006 Mar;27(3):224-8. doi: 10.1016/j.ijantimicag.2005.10.012. Epub 2006 Feb 7.
5
In vitro synergistic effect of colistin and ampicillin/sulbactam with several antibiotics against clinical strains of multi-drug resistant Acinetobacter baumannii.多黏菌素与氨苄西林/舒巴坦联合几种抗菌药物对多重耐药鲍曼不动杆菌临床分离株的体外协同作用。
Indian J Med Microbiol. 2021 Jul;39(3):358-362. doi: 10.1016/j.ijmmb.2021.04.006. Epub 2021 Apr 24.
6
[Evaluation of Colistin-Ampicillin/Sulbactam Combination Efficacy in Imipenem-Resistant Acinetobacter baumannii Strains].[多黏菌素-氨苄西林/舒巴坦联合用药对耐亚胺培南鲍曼不动杆菌菌株的疗效评估]
Mikrobiyol Bul. 2013 Jan;47(1):147-51. doi: 10.5578/mb.4523.
7
In Vitro Synergistic Activity of Antimicrobial Agents in Combination against Clinical Isolates of Colistin-Resistant Acinetobacter baumannii.抗菌药物联合对耐黏菌素鲍曼不动杆菌临床分离株的体外协同活性
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6774-6779. doi: 10.1128/AAC.00839-16. Print 2016 Nov.
8
[Do different interpretative methods used for evaluation of checkerboard synergy test affect the results?].[用于评估棋盘协同试验的不同解释方法会影响结果吗？]
Mikrobiyol Bul. 2012 Jul;46(3):410-20.
9
Ultrastructural changes caused by the combination of intravenous immunoglobulin with meropenem, amikacin and colistin in multidrug-resistant Acinetobacter baumannii.静脉注射用免疫球蛋白联合美罗培南、阿米卡星和黏菌素对多重耐药鲍曼不动杆菌的超微结构改变。
Microb Pathog. 2020 Dec;149:104437. doi: 10.1016/j.micpath.2020.104437. Epub 2020 Oct 9.
10
A prospective evaluation of synergistic effect of sulbactam and tazobactam combination with meropenem or colistin against multidrug resistant Acinetobacter baumannii.舒巴坦和他唑巴坦与美罗培南或黏菌素联合使用对多重耐药鲍曼不动杆菌协同作用的前瞻性评估。
Bosn J Basic Med Sci. 2015 Oct 14;15(4):24-9. doi: 10.17305/bjbms.2015.526.
引用本文的文献
1
Comparison of the Efficacy of Adding Inhaled Levofloxacin and Colistin to a Basic Regimen of Colistin and Meropenem in the Treatment of Ventilator-associated Pneumonia Caused by Multidrug-resistant Gram-negative Bacteria: A Randomized Open-label Clinical Trial.在多药耐药革兰氏阴性菌所致呼吸机相关性肺炎治疗中，吸入用左氧氟沙星和黏菌素添加至黏菌素和美罗培南基础方案的疗效比较：一项随机开放标签临床试验
J Res Pharm Pract. 2025 Jun 13;14(1):9-17. doi: 10.4103/jrpp.jrpp_12_25. eCollection 2025 Jan-Mar.
2
Enhancing colistin efficacy with combination therapies for multidrug-resistant and isolates.采用联合疗法提高多药耐药菌和分离株对黏菌素的疗效。
Future Microbiol. 2025 May-Jun;20(7-9):523-531. doi: 10.1080/17460913.2025.2490377. Epub 2025 Apr 10.
3
Colistin: Lights and Shadows of an Older Antibiotic.多黏菌素：一种老抗生素的光明与黑暗。
Molecules. 2024 Jun 21;29(13):2969. doi: 10.3390/molecules29132969.
4
Rifampicin Enhanced Carbapenem Activity with Improved Antibacterial Effects and Eradicates Established Biofilms.利福平增强碳青霉烯类活性，具有改善的抗菌效果并根除已形成的生物膜。
Pharmaceuticals (Basel). 2023 Mar 23;16(4):477. doi: 10.3390/ph16040477.
5
The effectiveness of colistin/levofloxacin compared to colistin/meropenem in the treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant : a randomized controlled clinical trial.与黏菌素/美罗培南相比，黏菌素/左氧氟沙星治疗耐碳青霉烯类引起的呼吸机相关性肺炎（VAP）的有效性：一项随机对照临床试验。
Res Pharm Sci. 2022 Dec 24;18(1):39-48. doi: 10.4103/1735-5362.363594. eCollection 2023 Feb.
6
Synergism versus Additivity: Defining the Interactions between Common Disinfectants.协同作用与相加作用：定义常见消毒剂之间的相互作用。
mBio. 2021 Oct 26;12(5):e0228121. doi: 10.1128/mBio.02281-21. Epub 2021 Sep 21.
7
Effect of combined colistin and meropenem against meropenem resistant and by checkerboard method: A cross sectional analytical study.联合黏菌素和美罗培南对抗美罗培南耐药鲍曼不动杆菌的效果：一项棋盘法的横断面分析研究。
Indian J Pharmacol. 2021 May-Jun;53(3):207-212. doi: 10.4103/ijp.ijp_1013_20.
8
Evaluation of the Synergistic Antibacterial Effects of Fosfomycin in Combination with Selected Antibiotics against Carbapenem-Resistant .磷霉素与选定抗生素联合使用对耐碳青霉烯类细菌的协同抗菌作用评估
Pharmaceuticals (Basel). 2021 Feb 25;14(3):185. doi: 10.3390/ph14030185.
9
Synergistic antibacterial effects of colistin in combination with aminoglycoside, carbapenems, cephalosporins, fluoroquinolones, tetracyclines, fosfomycin, and piperacillin on multidrug resistant Klebsiella pneumoniae isolates.多黏菌素与氨基糖苷类、碳青霉烯类、头孢菌素类、氟喹诺酮类、四环素类、磷霉素和哌拉西林联合使用对多重耐药肺炎克雷伯菌的协同抗菌作用。
PLoS One. 2021 Jan 6;16(1):e0244673. doi: 10.1371/journal.pone.0244673. eCollection 2021.
10
In Vitro Activities of Colistin and Sitafloxacin Combinations against Multidrug-, Carbapenem-, and Colistin-Resistant Using the Broth Microdilution Checkerboard and Time-Kill Methods.采用肉汤微量稀释棋盘法和时间杀菌法检测多粘菌素与西他沙星联合用药对多重耐药、碳青霉烯耐药和多粘菌素耐药菌的体外活性。
Antibiotics (Basel). 2020 Aug 14;9(8):516. doi: 10.3390/antibiotics9080516.
本文引用的文献
1
Synergy effect of meropenem-based combinations against : a systematic review and meta-analysis.基于美罗培南的联合用药对……的协同效应：一项系统评价与荟萃分析
Infect Drug Resist. 2018 Aug 7;11:1083-1095. doi: 10.2147/IDR.S172137. eCollection 2018.
2
Evaluating Adherence of Health-Care Team to Standard Guideline of Colistin Use at Intensive Care Units of a Referral Hospital in Shiraz, Southwest of Iran.评估伊朗西南部设拉子一家转诊医院重症监护病房医护团队对黏菌素使用标准指南的依从性。
Adv Pharm Bull. 2017 Sep;7(3):391-397. doi: 10.15171/apb.2017.047. Epub 2017 Sep 25.
3
Infections Due to Acinetobacter baumannii in the ICU: Treatment Options.重症监护病房中鲍曼不动杆菌感染：治疗选择
Semin Respir Crit Care Med. 2017 Jun;38(3):311-325. doi: 10.1055/s-0037-1599225. Epub 2017 Jun 4.
4
Synergistic Effect of Colistin and Rifampin Against Multidrug Resistant : A Systematic Review and Meta-Analysis.黏菌素与利福平对多重耐药菌的协同作用：一项系统评价与荟萃分析
Open Microbiol J. 2017 Apr 28;11:63-71. doi: 10.2174/1874285801711010063. eCollection 2017.
5
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.不动杆菌感染的临床与病理生理学概述：一个世纪的挑战
Clin Microbiol Rev. 2017 Jan;30(1):409-447. doi: 10.1128/CMR.00058-16.
6
Task force on management and prevention of Acinetobacter baumannii infections in the ICU.**重症监护病房鲍曼不动杆菌感染管理与预防工作组**
Intensive Care Med. 2015 Dec;41(12):2057-75. doi: 10.1007/s00134-015-4079-4. Epub 2015 Oct 5.
7
Phenotypic and Molecular Epidemiology of Acinetobacter calcoaceticus baumannii Complex Strains Spread at Nemazee Hospital of Shiraz, Iran.在伊朗设拉子内马齐医院传播的鲍曼不动杆菌复合菌株的表型和分子流行病学
Jundishapur J Microbiol. 2015 Jun 20;8(6):e19180. doi: 10.5812/jjm.8(5)2015.19180. eCollection 2015 Jun.
8
In vitro synergy of colistin combinations against extensively drug-resistant Acinetobacter baumannii producing OXA-23 carbapenemase.针对产OXA-23碳青霉烯酶的广泛耐药鲍曼不动杆菌，黏菌素联合用药的体外协同作用
J Chemother. 2016 Jun;28(3):159-63. doi: 10.1179/1973947815Y.0000000030. Epub 2016 Apr 22.
9
In Vitro Fractional Inhibitory Concentration (FIC) Study of Cefixime and Azithromycin Fixed Dose Combination (FDC) Against Respiratory Clinical Isolates.头孢克肟与阿奇霉素固定剂量复方制剂（FDC）对呼吸道临床分离株的体外部分抑菌浓度（FIC）研究
J Clin Diagn Res. 2015 Feb;9(2):DC13-5. doi: 10.7860/JCDR/2015/12092.5560. Epub 2015 Feb 1.
10
Synergistic interactions between colistin and meropenem against extensively drug-resistant and pandrug-resistant Acinetobacter baumannii isolated from ICU patients.黏菌素和美罗培南对从重症监护病房患者中分离出的广泛耐药和泛耐药鲍曼不动杆菌的协同相互作用。
Int J Antimicrob Agents. 2015 Jun;45(6):670-1. doi: 10.1016/j.ijantimicag.2015.02.005. Epub 2015 Feb 26.
Zotero 插件