Sussman Tamara A, Khunger Monica, Velcheti Vamsidhar
Cleveland Clinic Foundation, 9500 Euclid ave, Cleveland, OH 44195, OH, USA.
Lung Cancer Manag. 2017 Jul;6(1):5-7. doi: 10.2217/lmt-2016-0017. Epub 2017 Jul 14.
We report a case of crizotinib-induced esophageal ulcers in a 45-year-old woman with metastatic anaplastic lymphoma kinase-positive non-small-cell lung cancer after 10 weeks of therapy. Endoscopic and pathologic findings were consistent with active inflammation with mid-esophageal ulceration and consistent with drug-induced esophagitis. Crizotinib was held and had a complete clinical and radiographic resolution of her symptoms. Patient was started on treatment with another anaplastic lymphoma kinase-targeted agent alectinib and has been tolerating it well without evidence of recurrence of esophagitis.
我们报告了一例45岁转移性间变性淋巴瘤激酶阳性非小细胞肺癌女性患者，在接受克唑替尼治疗10周后出现克唑替尼诱导的食管溃疡。内镜和病理检查结果与食管中段溃疡的活动性炎症一致，符合药物性食管炎表现。停用克唑替尼后，患者症状在临床和影像学上完全缓解。患者开始接受另一种间变性淋巴瘤激酶靶向药物阿来替尼治疗，耐受性良好，无食管炎复发迹象。
