脂联素的血清和支气管肺泡灌洗水平在晚期非小细胞肺癌中的预后价值
The prognostic value of serum and bronchoalveolar lavage levels of adiponectin in advanced non-small-cell lung cancer.
作者信息
Boura Paraskevi, Grapsa Dimitra, Loukides Stylianos, Angelidou Maria, Tsakanika Konstantina, Syrigos Nikolaos, Gkiozos Ioannis
机构信息
Oncology Unit GPP, 'Sotiria' General Hospital, Medical School, University of Athens, 11527, Athens, Greece.
3rd Pulmonary Department, Sismanoglio General Hospital, 15126, Athens, Greece.
出版信息
Lung Cancer Manag. 2017 Nov;6(2):55-65. doi: 10.2217/lmt-2016-0018. Epub 2017 Nov 17.
AIM
We aimed to explore the prognostic implications of adiponectin (APN) levels in the serum and bronchoalveolar lavage (BAL) of patients with advanced NSCLC.
MATERIALS & METHODS: 29 newly diagnosed patients with stage IV NSCLC were prospectively enrolled. Baseline serum and BAL levels of APN were assayed by ELISA and correlated with various clinicopathological parameters, including overall survival.
RESULTS
No statistically significant correlations were observed between the serum or BAL levels of APN and the clinicopathological parameters evaluated. The only prognostic factor identified, both by univariate and multivariate survival analyses, was performance status.
CONCLUSION
The results of our cohort failed to reveal any prognostic significance of serum and BAL levels of APN in stage IV NSCLC.
目的
我们旨在探讨晚期非小细胞肺癌（NSCLC）患者血清和支气管肺泡灌洗（BAL）中脂联素（APN）水平的预后意义。
材料与方法
前瞻性纳入29例新诊断的IV期NSCLC患者。采用酶联免疫吸附测定（ELISA）法检测APN的基线血清和BAL水平，并将其与包括总生存期在内的各种临床病理参数相关联。
结果
未观察到APN的血清或BAL水平与所评估的临床病理参数之间存在统计学显著相关性。单因素和多因素生存分析确定的唯一预后因素是体能状态。
结论
我们队列的结果未能揭示IV期NSCLC患者血清和BAL中APN水平的任何预后意义。
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