肺癌患者血清和支气管肺泡灌洗液中的胃泌素水平：与慢性阻塞性肺疾病患者的比较。
Gastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease.
作者信息
Dowlati A, Bury T, Corhay J L, Weber T, Lamproye A, Mendes P, Radermecker M
机构信息
Department of Internal Medicine, University of Liège, School of Medicine, Belgium.
出版信息
Thorax. 1996 Dec;51(12):1270-2. doi: 10.1136/thx.51.12.1270.
BACKGROUND
The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and serum of patients with lung cancer. Based on these preliminary data a study was conducted to evaluate the usefulness of gastrin measurements in the diagnosis and staging of lung cancer.
METHODS
Thirty-five patients with lung cancer (26 non-small cell (NSCLC) and nine small cell (SCLC)) and 25 patients with chronic obstructive pulmonary disease underwent fibreoptic bronchoscopy and BAL. Gastrin levels were determined in both BAL fluid and the serum and compared with each other and with staging.
RESULTS
No difference was found between the gastrin levels in the BAL fluid or serum of the study groups. There was no correlation with the stage in NSCLC and no correlation was found between the gastrin levels in the serum and the BAL fluid. A significant difference was seen in gastrin levels in BAL fluid between extensive and limited SCLC (p < 0.05).
CONCLUSION
There is no evidence of clinical usefulness for gastrin measurements in lung cancer.
背景
已知胃泌素基因在所有类型的支气管癌中均有表达。此外，据报道肺癌患者的支气管肺泡灌洗（BAL）液和血清中胃泌素水平均较高。基于这些初步数据，开展了一项研究以评估胃泌素检测在肺癌诊断和分期中的作用。
方法
35例肺癌患者（26例非小细胞肺癌（NSCLC）和9例小细胞肺癌（SCLC））以及25例慢性阻塞性肺疾病患者接受了纤维支气管镜检查和BAL。测定了BAL液和血清中的胃泌素水平，并进行相互比较以及与分期进行比较。
结果
研究组的BAL液或血清中的胃泌素水平之间未发现差异。NSCLC中胃泌素水平与分期无相关性，血清和BAL液中的胃泌素水平之间也未发现相关性。广泛期和局限期SCLC的BAL液中胃泌素水平存在显著差异（p < 0.05）。
结论
没有证据表明胃泌素检测对肺癌具有临床应用价值。
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