Research Unit on Gerontology, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, MEX, Mexico.
Hematopoiesis and Leukemia Laboratory, Research Unit on Cell Differentiation and Cancer, FES Zaragoza, National Autonomous University of Mexico, 09230 Mexico City, MEX, Mexico.
Curr Pharm Des. 2018;24(40):4807-4824. doi: 10.2174/1381612824666190114164758.
Oxidative stress (OxS) is a biochemical process characterized by an imbalance between the production of reactive species (RS) and antioxidants in favor of the former that subsequently induces the oxidative damage of biomolecules and alters cellular physiology. OxS exerts diverse effects and is associated with the pathophysiology of more than 100 diseases, as well as with the aging process. OxS also plays a role in maintaining the homeostasis of both animal and plant organisms. We analyze the role and mechanisms of the generation of RS and antioxidants both under physiological conditions and during aging and pathological processes. Likewise, the potential of antioxidant agents from the diet is considered, specifically fruits such as chayote. We focus on naringenin, a flavonoid with a high antioxidant capacity.
We conducted a literature review to present the state of the art of knowledge about the biological significance of oxidative stress and the effect of antioxidants in some edible fruits.
Evidence supports the existence of RS, their physiological roles as well its harmful effects when oxidative stress occurs. In this sense, given the association of oxidative stress with diseases and aging the fruits rich in antioxidants are a feasible alternative to restore de redox balance if necessary.
氧化应激（OxS）是一种生化过程，其特征是活性物质（RS）的产生与抗氧化剂之间失去平衡，有利于前者，随后导致生物分子的氧化损伤，并改变细胞生理学。OxS 发挥多种作用，与 100 多种疾病的病理生理学以及衰老过程有关。OxS 也在维持动物和植物生物体的内稳态中发挥作用。我们分析了在生理条件下以及衰老和病理过程中 RS 和抗氧化剂的产生的作用和机制。同样，考虑了饮食中抗氧化剂的潜在作用，特别是像佛手瓜这样的水果。我们专注于柚皮苷，一种具有高抗氧化能力的类黄酮。
我们进行了文献综述，介绍了氧化应激的生物学意义以及一些食用水果中抗氧化剂的作用的最新知识状况。
有证据表明 RS 的存在及其在氧化应激发生时的生理作用及其有害影响。在这方面，鉴于氧化应激与疾病和衰老的关联，如果需要，富含抗氧化剂的水果是恢复氧化还原平衡的可行选择。
