Department of Dermatology, University of California, Davis School of Medicine, Sacramento, CA 95616, USA.
Skin Pharmacol Physiol. 2011;24(3):113-26. doi: 10.1159/000322643. Epub 2011 Jan 15.
Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.
许多受氧化还原控制的伤口愈合方面都需要在氧化应激和抗氧化剂之间保持微妙的平衡。虽然伤口愈合的正常生理机能依赖于低水平的活性氧和氧化应激，但过度暴露于氧化应激会导致伤口愈合受损。抗氧化剂被认为有助于控制伤口的氧化应激，从而加速伤口愈合。有许多抗氧化剂可在柜台或处方购买，但只有一种，Medihoney®，已被 FDA 专门批准用于伤口愈合。在这里，我们回顾了使用抗氧化剂治疗伤口愈合的现有证据，同时回顾了相关的动物和临床研究。天然产品和天然衍生的抗氧化剂越来越受欢迎，我们特别审查了天然衍生的抗氧化剂在伤口愈合中的应用证据。抗氧化剂治疗伤口愈合有很大的前景，但只有少数动物研究，甚至更少的临床研究可用。由于只有少数产品获得了 FDA 的批准，建议消费者在使用前仔细检查它们的纯度和污染物，这可能需要直接与销售它们的公司联系。作为一个科学领域，抗氧化剂治疗伤口愈合还处于起步阶段，未来的研究将更好地阐明抗氧化剂在伤口愈合中的作用。
