Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, 201303, India.
Department of Biochemistry, Central University of Haryana, Jant-Pali, Mahendergarh District-123031, Haryana, India.
Curr Pharm Des. 2018;24(40):4711-4725. doi: 10.2174/1381612825666190115121018.
Neurodegenerative diseases are becoming more and more common in today's world. As people are continuously being exposed to exogenous factors like UV radiations, gamma rays, X-Rays, environmental pollutants and heavy metals, the cases of increased oxidative damage are increasing. Even though some amount of oxidative damage occurs in all metabolic reactions but their increase from the normal level in organisms causes neurodegenerative diseases. These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in physiological and psychological functions caused by ROS and RNS. These ROS and RNS are formed as the result of excess oxidative damage in the system.
The following article goes into detail explaining all the effects caused by excess oxidative damage like ROS/RNS formation and telomere shortening. Further, it explains the pathways of neurodegenerative diseases and neuropsychiatric diseases. This article also sheds light on the effective treatments of such disorders by changing lifestyle and activating antioxidant pathways.
It is clear that neurodegenerative diseases are caused due to excess oxidative stress and alter the functioning of the central nervous system. The central nervous system undergoes neurodegenerative or neuropsychiatric changes.
在当今世界，神经退行性疾病变得越来越普遍。由于人们不断接触到紫外线辐射、伽马射线、X 射线、环境污染物和重金属等外源因素，氧化损伤的病例越来越多。尽管所有代谢反应中都会发生一定量的氧化损伤，但如果它们的水平超过了正常水平，就会导致神经退行性疾病。这些神经退行性疾病，如阿尔茨海默病、帕金森病和神经精神疾病，如精神分裂症、双相情感障碍、抑郁症，是由于 ROS 和 RNS 引起的生理和心理功能下降而导致的。这些 ROS 和 RNS 是由于系统中过量氧化损伤而形成的。
本文详细解释了过量氧化损伤（如 ROS/RNS 形成和端粒缩短）所引起的所有影响。此外，它还解释了神经退行性疾病和神经精神疾病的途径。本文还通过改变生活方式和激活抗氧化途径来阐明对这些疾病的有效治疗方法。
很明显，神经退行性疾病是由过量的氧化应激引起的，并改变了中枢神经系统的功能。中枢神经系统会发生神经退行性或神经精神变化。
