Sönnichsen N, Meffert H, Gruner S, Böhm F, Scherf H P
Dermatologischen Klinik und Poliklinik, Bereichs Medizin, Humboldt-Universität zu Berlin.
Z Gesamte Inn Med. 1988 Nov 15;43(22):634-8.
Sunshine is one of mankind's oldest remedies. Merely forgotten, UV light treatment came back recently due to (1) technological progress, providing particular UV wavelengths (2) basic research, discovering mode of action at molecular level, and (3) rising knowledge about skin as the primary target. Human skin is a rather difficult organ, possessing a considerable part of the immune system, the so-called skin associated lymphoid tissue. Different biological effects are caused by UV irradiation at different wavelengths. UV radiation alone as well as together with a photosensitizer also can cause systemic effects. Dealing with these, results of basic research and their application on modern treatment of some skin diseases, transplantation medicine, non-specific resistance system, and treatment of cardiovascular diseases are discussed.
阳光是人类最古老的治疗手段之一。紫外线光疗只是被遗忘了，近来由于以下原因又重新兴起：（1）技术进步，能提供特定的紫外线波长；（2）基础研究，在分子水平上发现了其作用方式；（3）对皮肤作为主要靶点的认识不断提高。人体皮肤是一个相当复杂的器官，拥有免疫系统的相当一部分，即所谓的皮肤相关淋巴组织。不同波长的紫外线照射会产生不同的生物学效应。单独的紫外线辐射以及与光敏剂一起使用也会产生全身效应。本文将探讨基础研究的结果及其在某些皮肤病的现代治疗、移植医学、非特异性抵抗系统和心血管疾病治疗中的应用。
