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下肢软组织肉瘤切除术后肢体挽救重建手术:20年经验

Reconstructive limb-salvage surgery after lower extremity soft tissue sarcoma resection: A 20-year experience.

作者信息

Bridgham Kelly M, El Abiad Jad M, Lu Zhen A, Bhat Deepa, Darrach Halley, Morris Carol D, Levin Adam S, Sacks Justin M

机构信息

Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

J Surg Oncol. 2019 May;119(6):708-716. doi: 10.1002/jso.25358. Epub 2019 Jan 15.

Abstract

BACKGROUND

Reconstructive surgery is often required following lower extremity soft tissue sarcoma resection. The relationship between the method of plastic surgery reconstruction and postoperative wound healing or functional oncologic outcomes in this patient population is poorly understood.

METHODS

We performed a retrospective review on all adult patients that underwent soft tissue reconstruction following resection of lower extremity soft tissue sarcomas between 1996 and 2016 at our institution.

RESULTS

One hundred and thirty-six patients were identified. Wound complications occurred within 6-months postoperatively in 72 patients (52.9%). Average time to heal was 13.0 weeks. Limb survival was 94.9%. 16.9% and 36.8% of patients had evidence of local recurrence or metastatic disease, respectively. There was no significant difference in the incidence of overall wound complications, time to heal, limb survival, local recurrence, or metastatic disease between the different reconstructive methods.

CONCLUSIONS

In our cohort, the utilization of different reconstructive techniques did not correlate with a difference in postoperative wound complications or oncologic outcomes. Local flaps can effectively reconstruct the majority of lower extremity sarcoma defects that cannot be closed primarily. However, alternative reconstructive techniques may be utilized when indicated without a significant increase in postoperative morbidity in this patient population.

摘要

背景

下肢软组织肉瘤切除术后常需进行重建手术。在这类患者中,整形手术重建方法与术后伤口愈合或肿瘤功能学结局之间的关系尚不清楚。

方法

我们对1996年至2016年在我院接受下肢软组织肉瘤切除术后进行软组织重建的所有成年患者进行了回顾性研究。

结果

共纳入136例患者。72例患者(52.9%)在术后6个月内出现伤口并发症。平均愈合时间为13.0周。肢体存活率为94.9%。分别有16.9%和36.8%的患者有局部复发或转移疾病的证据。不同重建方法之间在总体伤口并发症发生率、愈合时间、肢体存活率、局部复发或转移疾病方面无显著差异。

结论

在我们的队列中,不同重建技术的应用与术后伤口并发症或肿瘤学结局的差异无关。局部皮瓣可有效重建大多数无法一期闭合的下肢肉瘤缺损。然而,在有指征时可采用其他重建技术,而不会显著增加该患者群体的术后发病率。

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