Department of Endocrinology, Wuhan General Hospital of Chinese People's Liberation Army, Wuhan, China.
Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, Georgia.
Aging Cell. 2019 Apr;18(2):e12883. doi: 10.1111/acel.12883. Epub 2019 Jan 15.
Alogliptin is a commonly prescribed drug treating patients with type 2 diabetes. Here, we show that long-term intervention with alogliptin (0.03% w/w in diet) improves survival and health of mice on a high-fat diet. Alogliptin intervention takes beneficial effects associated with longevity, including increased insulin sensitivity, attenuated functionality decline, decreased organ pathology, preserved mitochondrial function, and reduced oxidative stress. Autophagy activation is proposed as an underlying mechanism of these beneficial effects. We conclude that alogliptin intervention could be considered as a potential strategy for extending lifespan and healthspan in obesity and overweight.
阿格列汀是一种常用于治疗 2 型糖尿病患者的药物。在这里，我们表明，长期使用阿格列汀（饮食中 0.03%w/w）干预可改善高脂肪饮食小鼠的生存和健康状况。阿格列汀干预具有与长寿相关的有益效果，包括增加胰岛素敏感性、减弱功能下降、减少器官病变、维持线粒体功能和减少氧化应激。自噬激活被认为是这些有益效果的潜在机制。我们得出结论，阿格列汀干预可以被认为是一种延长肥胖和超重人群寿命和健康寿命的潜在策略。
