Wang Tian-Zhan, Huo Qing-Ping, Fu Xiao-Dong, He Yan-Ming, Wang Wen-Jian
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Sep;36(9):1065-1071.
Objective To observe clinical efficacy of Yiqi Huaju Recipe (YHR) combined routine Western medical treatment on type 2 diabetes mellitus (T2DM) patients complicated metabolic syndrome (MetS). Methods Totally 96 T2DM patients complicated MetS were assigned to the treatment group (YHR +routine Western drugs) and the control group (placebo +routine Western drugs) according to random digit table, 48 cases in each group. The therapeutic course for all was 12 weeks. Body mass index (BMI) , waistline, waist-hip ratio (WHR) , fasting plasma glucose (FPG) , 2 h postprandial plasma glucose (2 h PPG) , glycosylated hemoglobin A1c (HbAlc) , homeostasis model assessment of insulin resistance (HOMA-IR) , blood lipids, blood pressure, disease transformation of MetS, changes of con- stituent numbers were detected before and after treatment. Results BMI, WHR, waistline obviously decreased in the treatment group after treatment, with statistical difference as compared with the control group (P<0.01 , P <0.05). Post-treatment FPG, 2 h PPG, HbAlc, HOMA-IR, systolic blood pressure (SBP), diastolic blood pressure (DBP) , and mean artery pressure (MAP) obviously decreased in the two groups, but more obviously in the treatment group (P <0. 05). Post-treatment total cholesterol (TC) , low density lipoprotein cholesterol (LDL-C) , and triglycerides (TG) all obviously decreased in the two groups , but TG decreased more obviously in the treatment group (P <0. 05). High density lipoprotein cholesterol (HDL-C) obviously increased in the treatment group (P <0. 05). Patient numbers of central obesity, uncontrolled hypertension, and uncontrolled diabetes obviously decreased and constituent numbers were obviously reduced in the treatment group after treatment, with better efficacy than those of the control group (P <0. 01 , P <0. 05). Conclusions YHR plus routine Western drugs could further reduce blood glucose, and had comprehensive interventional effects on multiple cardiovascular risk factors such as central obesity, blood lipids, and blood pressure in T2DM patients complicated with MetS. Its mechanism might be possibly correlated with improving insulin resistance and elevating insulin sensitivity of peripheral tissues.
目的 观察益气化浊方（YHR）联合常规西药治疗2型糖尿病（T2DM）合并代谢综合征（MetS）患者的临床疗效。方法 将96例T2DM合并MetS患者按随机数字表法分为治疗组（YHR+常规西药）和对照组（安慰剂+常规西药），每组48例。全部疗程为12周。检测治疗前后患者的体重指数（BMI）、腰围、腰臀比（WHR）、空腹血糖（FPG）、餐后2小时血糖（2 h PPG）、糖化血红蛋白A1c（HbAlc）、胰岛素抵抗稳态模型评估（HOMA-IR）、血脂、血压、MetS病情转归、组分个数变化。结果 治疗组治疗后BMI、WHR、腰围明显降低，与对照组比较差异有统计学意义（P<0.01，P<0.05）。两组治疗后FPG、2 h PPG、HbAlc、HOMA-IR、收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）均明显降低，但治疗组更明显（P<0.05）。两组治疗后总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）均明显降低，但治疗组TG降低更明显（P<0.05）。治疗组高密度脂蛋白胆固醇（HDL-C）明显升高（P<0.05）。治疗组治疗后中心性肥胖、高血压未控制、糖尿病未控制的患者数明显减少，组分个数明显减少，疗效优于对照组（P<0.01，P<0.05）。结论 YHR联合常规西药可进一步降低血糖，对T2DM合并MetS患者的中心性肥胖、血脂、血压等多种心血管危险因素有综合干预作用。其机制可能与改善胰岛素抵抗、提高外周组织胰岛素敏感性有关。
