劫持 EMT：宁愿肥胖也不愿死亡。
Hijacking EMT: Better Fat Than Dead.
机构信息
Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
Department of Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA.
出版信息
Cancer Cell. 2019 Jan 14;35(1):1-2. doi: 10.1016/j.ccell.2018.12.007.
PMID:30645968
Abstract
Potential for cancers to form metastases requires cell dissemination utilizing epithelial-to-mesenchymal transition (EMT) program. In this issue of Cancer Cell, Ishay-Ronen et al. show that plasticity intrinsic to the EMT program can be exploited to divert cancer cells into becoming post-mitotic adipocytes, thus preventing formation of metastases.
摘要
肿瘤形成转移的潜力需要利用上皮-间充质转化（EMT）程序进行细胞扩散。在本期《癌细胞》杂志中，Ishay-Ronen 等人表明，EMT 程序所具有的固有可塑性可以被利用来促使癌细胞变成有丝分裂后脂肪细胞，从而防止转移的形成。
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