短链脂肪酸在癌症预防和治疗中的作用。
The role of short-chain fatty acids in cancer prevention and cancer treatment.
机构信息
Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, United States.
Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, United States.
出版信息
Arch Biochem Biophys. 2024 Nov;761:110172. doi: 10.1016/j.abb.2024.110172. Epub 2024 Oct 4.
Short-chain fatty acids (SCFAs) are microbial metabolites in the gut that may play a role in cancer prevention and treatment. They affect the metabolism of both normal and cancer cells, regulating various cellular energetic processes. SCFAs also inhibit histone deacetylases, which are targets for cancer therapy. The three main SCFAs are acetate, propionate, and butyrate, which are transported into cells through specific transporters. SCFAs may enhance the efficacy of chemotherapeutic agents and modulate immune cell metabolism, potentially reprogramming the tumor microenvironment. Although SCFAs and SCFA-generating microbes enhance therapeutic efficacy of several forms of cancer therapy, published data also support the opposing viewpoint that SCFAs mitigate the efficacy of some cancer therapies. Therefore, the relationship between SCFAs and cancer is more complex, and this review discusses some of these aspects. Clearly, further research is needed to understand the role of SCFAs, their mechanisms, and applications in cancer prevention and treatment.
短链脂肪酸（SCFAs）是肠道中的微生物代谢产物，可能在癌症的预防和治疗中发挥作用。它们影响正常细胞和癌细胞的代谢，调节各种细胞能量过程。SCFAs 还抑制组蛋白去乙酰化酶，这是癌症治疗的靶点。三种主要的 SCFAs 是乙酸盐、丙酸盐和丁酸盐，它们通过特定的转运蛋白进入细胞。SCFAs 可以增强化疗药物的疗效，并调节免疫细胞的代谢，可能重塑肿瘤微环境。尽管 SCFAs 和产生 SCFA 的微生物增强了几种形式的癌症治疗的疗效，但已发表的数据也支持相反的观点，即 SCFAs 减轻了一些癌症治疗的疗效。因此，SCFAs 与癌症之间的关系更为复杂，本综述讨论了其中的一些方面。显然，需要进一步的研究来了解 SCFAs 的作用、它们的机制以及在癌症预防和治疗中的应用。
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