Arthur and Sonia Labatt Brain Tumour Research Centre, Department of Pediatrics/Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada.
Arthur and Sonia Labatt Brain Tumour Research Centre, Department of Pediatrics/Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5S3H7, Canada.
Cancer Cell. 2019 Jan 14;35(1):7-9. doi: 10.1016/j.ccell.2018.12.005.
Diffuse intrinsic brain stem gliomas (DIPGs) with characteristic K27M mutation of H3.3 are lethal and poorly understood childhood cancers. In this issue of Cancer Cell, Larson et al. exploit a unique murine DIPG model with inducible, endogenous K27M expression to reveal insights into mechanisms of K27M-mediated transformation in DIPG.
弥漫性内在脑桥神经胶质瘤（DIPG）具有 H3.3 的特征性 K27M 突变，是一种致命且了解甚少的儿童癌症。在本期《癌细胞》杂志中，Larson 等人利用一种具有诱导性、内源性 K27M 表达的独特的小鼠 DIPG 模型，揭示了 DIPG 中 K27M 介导转化的机制。
