Denis J, Brunel P, Moisan A
Service de Cardiologie, Centre Hospitalier Général, Saint-Nazaire.
Ann Cardiol Angeiol (Paris). 1988 Jul-Sep;37(7):387-91.
20 patients with supraventricular tachycardia, received one to three intravenous injections of 0.5 mg/kg of sotalol. This group included 8 atrial fibrillations, 5 atrial flutters, 2 systolic tachycardias and 5 junctional tachycardias. Return to a normal sinus rhythm is obtained in 2 of the 8 patients with atrial fibrillation while a decreased heart rate under 100 per minute is noted in 3 of them. Among the 5 patients with atrial flutter, only one returned to a normal sinus rhythm and in 2 the tachycardia decreased. In the 2 patients with systolic tachycardia, the heart rate decreased without return to a normal sinus rhythm while the heart rate decreased in all 5 cases of junctional tachycardia. A left ventricular failure with hypotension, a bradycardia at 30/min. and a transient left bundle branch block were observed during treatment. The bundle branch block is explained by an increased ventricular effective, refractory period induced by this beta-blocker. Intravenous sotalol appears as an interesting alternative in the treatment of supraventricular tachycardias with an efficacy of about 70 p. cent; it is well tolerated if the contraindications of the beta-blockers are respected.
20例室上性心动过速患者接受了1至3次静脉注射，每次剂量为0.5mg/kg的索他洛尔。该组包括8例心房颤动、5例心房扑动、2例室性心动过速和5例交界性心动过速。8例心房颤动患者中有2例恢复为正常窦性心律，其中3例心率降至每分钟100次以下。5例心房扑动患者中，只有1例恢复为正常窦性心律，2例心动过速有所减缓。2例室性心动过速患者心率下降但未恢复为正常窦性心律，而5例交界性心动过速患者心率均下降。治疗期间观察到1例伴有低血压的左心室衰竭、1例心率为30次/分钟的心动过缓和1例短暂性左束支传导阻滞。束支传导阻滞是由这种β受体阻滞剂引起的心室有效不应期延长所致。静脉注射索他洛尔似乎是治疗室上性心动过速的一种有效替代方法，有效率约为70%；如果遵守β受体阻滞剂的禁忌证，其耐受性良好。
