Lévy S, Rovini J C, Metge M, Cointe R, Bru P, Nassi C, Gérard R
Arch Mal Coeur Vaiss. 1986 Nov;79(12):1781-5.
The effects of intravenous sotalol (0.5 mg/kg in 6 minutes) were studied in 23 patients with supraventricular tachycardia (ventricular rate greater than 120 bpm) after failure of placebo (isotonic dextrose). Thirteen patients had atrial flutter or fibrillation and 10 a junctional tachycardia of recent onset. Sinus rhythm was restored in 4 of the patients with atrial flutter or fibrillation and the ventricular rate was slowed significantly in 3 patients (less than 100 bpm). In 3 other patients the ventricular rate decreased (31 to 35 p. 100) but remained above 100 bpm. Sinus rhythm was restored in 3 of the 10 patients with a junctional tachycardia five to twelve minutes after beginning the injection. A slight slowing of the heart rate (13 to 27 p. 100) was observed in the other 7 patients but the frequency remained over 100 bpm. Overall, a satisfactory result was obtained in 10 patients (43 p. 100) including 7 cases in which sinus rhythm was restored. Sotalol was well tolerated in 21 patients; one patient complained of cold in the legs and one patient developed asymptomatic bradycardia (46 bpm). This study shows that intravenous sotalol may be useful in the emergency treatment of supraventricular tachycardia.
对23例室上性心动过速（心室率大于120次/分钟）患者在安慰剂（等渗葡萄糖）治疗无效后，研究了静脉注射索他洛尔（6分钟内注射0.5mg/kg）的效果。13例患者为心房扑动或心房颤动，10例为近期发作的交界性心动过速。13例心房扑动或心房颤动患者中有4例恢复窦性心律，3例患者心室率显著减慢（低于100次/分钟）。另外3例患者心室率下降（下降31%至35%）但仍高于100次/分钟。10例交界性心动过速患者中有3例在注射开始后5至12分钟恢复窦性心律。另外7例患者心率稍有减慢（减慢13%至27%），但频率仍超过100次/分钟。总体而言，10例患者（占43%）获得满意结果，其中7例恢复窦性心律。21例患者对索他洛尔耐受性良好；1例患者抱怨腿部发冷，1例患者出现无症状性心动过缓（46次/分钟）。本研究表明，静脉注射索他洛尔可能有助于室上性心动过速的急诊治疗。
