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特殊部位的银屑病。

Psoriasis in special localizations.

作者信息

Dopytalska Klaudia, Sobolewski Piotr, Błaszczak Agata, Szymańska Elżbieta, Walecka Irena

机构信息

Department of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland.

出版信息

Reumatologia. 2018;56(6):392-398. doi: 10.5114/reum.2018.80718. Epub 2018 Dec 23.

DOI:10.5114/reum.2018.80718
PMID:30647487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6330687/
Abstract

Psoriasis is a chronic inflammatory dermatosis affecting 1-3% of the general population. Patients with psoriasis represent a heterogeneous population with individual disease expression - different degrees and severity of skin involvement. Psoriatic lesions in particular localizations such as the face, scalp, intertriginous or palmoplantar areas significantly reduce quality of life. Patients often feel ashamed, embarrassed, or self-conscious about their symptoms. Furthermore, genital psoriasis significantly affects sexual health. Among patients with psoriasis, the prevalence of special localizations is estimated to be 23-27% on the nails, 49% on the face, 12-16% on the palms and soles, and up to 36% in intertriginous regions. Due to peculiar features of skin in these areas, adequate and specific management is required, which is discussed in this review.

摘要

银屑病是一种慢性炎症性皮肤病,影响着1%至3%的普通人群。银屑病患者群体具有异质性,个体疾病表现各异——皮肤受累程度和严重程度不同。银屑病在特定部位如面部、头皮、褶皱部位或掌跖部位的皮损会显著降低生活质量。患者常常对自己的症状感到羞愧、尴尬或自觉难为情。此外,生殖器银屑病会显著影响性健康。在银屑病患者中,特殊部位的患病率估计为:指甲23%至27%,面部49%,手掌和脚底12%至16%,褶皱部位高达36%。由于这些部位皮肤的特殊特征,需要进行充分且特定的管理,本综述将对此进行讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/9d48c5795471/RU-56-80718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/dfbe9af8fa75/RU-56-80718-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/a885df91f7ae/RU-56-80718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/9d48c5795471/RU-56-80718-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/dfbe9af8fa75/RU-56-80718-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/1781954e6716/RU-56-80718-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/8d74684ff3dc/RU-56-80718-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/a885df91f7ae/RU-56-80718-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11a0/6330687/9d48c5795471/RU-56-80718-g005.jpg

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2
Treatment of Genital Psoriasis: A Systematic Review.生殖器银屑病的治疗:一项系统评价。
Dermatol Ther (Heidelb). 2018 Dec;8(4):509-525. doi: 10.1007/s13555-018-0257-y. Epub 2018 Aug 25.
3
Efficacy and safety of ixekizumab in a randomized, double-blinded, placebo-controlled phase IIIb study of patients with moderate-to-severe genital psoriasis.
一份健康人类皮肤的转录组图谱将区域特征与炎症性疾病联系起来。
bioRxiv. 2025 May 15:2025.05.10.653184. doi: 10.1101/2025.05.10.653184.
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Components of Severity in Alopecia Areata.斑秃严重程度的组成部分。
Skin Appendage Disord. 2025 Apr 17:1-6. doi: 10.1159/000545861.
5
Roflumilast Foam, 0.3%, for Psoriasis of the Scalp and Body: The ARRECTOR Phase 3 Randomized Clinical Trial.0.3% 罗氟司特泡沫剂用于头皮和身体银屑病:ARRECTOR 3期随机临床试验
JAMA Dermatol. 2025 May 7. doi: 10.1001/jamadermatol.2025.1136.
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Roflumilast Cream 0.3% for a Patient With Genital Psoriasis Refractory to Other Topical and Systemic Treatments: A Case Report.0.3%罗氟司特乳膏治疗对其他局部和全身治疗无效的生殖器银屑病患者:一例报告
J Clin Aesthet Dermatol. 2025 Mar-Apr;18(3-4 Suppl 1):S24-S27.
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Hard-to-Treat Areas in Psoriasis: An Underevaluated Part of the Disease.银屑病的难治性区域:疾病中一个未得到充分评估的部分。
Life (Basel). 2025 Mar 7;15(3):425. doi: 10.3390/life15030425.
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Is there still a place for neutrophil gelatinase-associated lipocalin to serve as a biomarker in psoriasis?中性粒细胞明胶酶相关脂质运载蛋白作为银屑病生物标志物还有用吗?
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