Sibaii Hiba, El-Zayat Salwa Refat, El-Shaheed Azza Abd, Mahfouz Nermine N, Sallam Sara F, El Azma Marwa H
Medical Physiology Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.
Child Health Department, National Research Centre, Medical Division, 33 El-Bohouth Street, Dokki, POB:12311, Cairo, Egypt.
Open Access Maced J Med Sci. 2016 Dec 15;4(4):591-595. doi: 10.3889/oamjms.2016.134. Epub 2016 Nov 30.
There are no reports regarding the influence of vitamin D on thymosin ß4 and the cluster of differentiation CD4 levels which are important for maintaining a healthy immune system. Consequently, we aimed to explore this relationship through a study.
The study was carried out on 35 subjects, screened for 25-hydroxy vitamin D[25 (OH) D] using ELISA method and they were divided into two groups: Group 1 consists of 10 healthy subjects with sufficient vit. D level > 24.8 ng/ml. Group 2 consists of 25 subjects suffering, severely, from vitamin D deficiency at level < 11.325 ng/ml. Also, Thymosin ß4, CD4 and zinc levels were performed.
There were significant differences between the two groups in the concentration levels of thymosin β4, as the group 1 has shown higher levels (P = 0.005). Whereas, CD4 and zinc levels didn't show any significant difference between the two groups. At the same time, a significant positive correlation has been observed between vitamin D, thymosin β4, and CD4 at (r = 0.719; P = 0.001), and (r = 0.559, P = 0.001) respectively.
We concluded that vitamin D may be an essential factor that influence or determine the level of thymosin β4. This study is the first that focused on demonstrating that sufficient level of vitamin D may have the ability to influence the thymic hormone thymosin β4 levels. Further studies on large scale of subjects are needed to explore the positive correlation we had found between vitamin D and thymosin β4 and CD4.
关于维生素D对胸腺素β4以及对维持健康免疫系统很重要的分化簇CD4水平的影响，目前尚无相关报道。因此，我们旨在通过一项研究来探索这种关系。
该研究对35名受试者进行，采用酶联免疫吸附测定（ELISA）法对其25-羟基维生素D[25(OH)D]进行筛查，并将他们分为两组：第1组由10名维生素D水平充足（>24.8 ng/ml）的健康受试者组成。第2组由25名维生素D严重缺乏（水平<11.325 ng/ml）的受试者组成。此外，还检测了胸腺素β4、CD4和锌的水平。
两组之间胸腺素β4的浓度水平存在显著差异，第1组的水平更高（P = 0.005）。然而，两组之间的CD4和锌水平没有显示出任何显著差异。同时，观察到维生素D与胸腺素β4以及CD4之间分别存在显著正相关（r = 0.719；P = 0.001）和（r = 0.559，P = 0.001）。
我们得出结论，维生素D可能是影响或决定胸腺素β4水平的一个重要因素。本研究首次专注于证明充足的维生素D水平可能有能力影响胸腺激素胸腺素β4的水平。需要对大量受试者进行进一步研究，以探索我们发现的维生素D与胸腺素β4和CD4之间的正相关关系。
