Suito Motomu, Kitazawa Takeshi, Takashimizu Ikkei, Ikeda Tsuneko
Department of Plastic and Reconstructive Surgery, Matsunami General Hospital, 185-1, Dendai, Kasamatsu, Hashima-gun, Gifu, Japan.
Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Asahi, Matsumoto, Nagano, Japan.
J Surg Case Rep. 2019 Jan 9;2019(1):rjy356. doi: 10.1093/jscr/rjy356. eCollection 2019 Jan.
Madelung's disease (MD) is a rare lipid metabolic disorder of adipose tissue overgrowth, which has been reported to be related to alcohol abuse. Although it does not affect survival itself, alcoholism and metabolic disorders associated with MD can be life-threatening. Although surgical procedures and classifications have been reported, long-term follow-up has rarely been reported. Here, we report a 61-year-old Japanese man with MD who has been followed-up for 12 years. Lipectomy was performed three times over the first 3 years and a total of 4 kg of adipose tissue was excised. Relapse has not been observed. He was diagnosed with multiple hepatocellular carcinomas (MHC) and placed on dialysis due to hepatorenal syndrome caused by alcoholism. Moreover, one of the MHC ruptured resulting in hemorrhagic shock. The cause of death in MD is not fat proliferation but comorbidities. Long-term observation and multidisciplinary systemic management are necessary for MD patients.
马德隆病（MD）是一种罕见的脂肪组织过度生长的脂质代谢紊乱疾病，据报道与酒精滥用有关。虽然它本身不影响生存，但与MD相关的酗酒和代谢紊乱可能危及生命。尽管已经报道了手术方法和分类，但很少有长期随访的报道。在此，我们报告一名61岁的日本MD男性患者，其已接受了12年的随访。在最初的3年里进行了3次脂肪切除术，共切除了4千克脂肪组织。未观察到复发情况。他被诊断出患有多发性肝细胞癌（MHC），并因酗酒导致的肝肾综合征而接受透析治疗。此外，其中一个MHC破裂导致失血性休克。MD患者的死亡原因不是脂肪增生，而是合并症。对MD患者进行长期观察和多学科系统管理是必要的。
