Department of Molecular Chemistry & Biochemistry, Faculty of Science & Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan.
Chem Commun (Camb). 2019 Jan 29;55(10):1498-1501. doi: 10.1039/c8cc09051c.
A novel multiblock architecture composed of an alternating β-sheet forming oligopeptide and a thermo-responsive glycine-derived vinyl polymer was synthesized. The polymer exhibited lower critical solution temperature (LCST) behavior in water, unlike the behavior of a glycine-derived homopolymer, and formed nanoparticles through protein-mimicking folding driven by thermal cycle-induced β-sheet formation.
合成了一种由交替的β-折叠形成的寡肽和温敏性甘氨酸衍生的乙烯基聚合物组成的新型多嵌段结构。与甘氨酸衍生的均聚物不同，该聚合物在水中表现出较低的临界溶解温度（LCST）行为，并通过热循环诱导的β-折叠形成驱动的蛋白质模拟折叠形成纳米颗粒。
