血清前白蛋白与肝癌患者肝切除术后预后的相关性。
Correlation between serum prealbumin and prognosis of patients with hepatocellular carcinoma after hepatectomy.
作者信息
Jia Rong-Rong, Zhong Jian-Hong, Huo Rong-Rui, Su Qi-Bin, Xiang Xiao, Zhao Fu-Lin, Qin Zhong-Bian, Chen Jia-Hao, Liao Ying-Yang, Ma Liang, Xiang Bang-De, Zhang Chun-Yan, Li Le-Qun
机构信息
Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Center, Nanning, China.
出版信息
J Surg Oncol. 2019 May;119(6):794-800. doi: 10.1002/jso.25378. Epub 2019 Jan 15.
OBJECTIVE
To determine whether serum prealbumin levels are associated with long-term survival after hepatectomy in patients with primary hepatocellular carcinoma(HCC).
METHODS
A consecutive sample of 526 patients with HCC who underwent potentially curative hepatectomy from August 2007 to August 2010 was retrospectively analyzed. Patients were classified as having normal or reduced serum prealbumin based on cut-off values of 200 or 182 mg/L.
RESULTS
Multivariate analysis identified the preoperative level of serum prealbumin as an independent prognostic factor of long-term survival (P < 0.05): Survival was significantly better for those with normal levels than for those with reduced levels, based on either cut-off value. Similar results were observed in subgroup analyses based on the degree of cirrhosis, level of ɑ-fetoprotein and Barcelona Clinic Liver Cancer stage.
CONCLUSIONS
Preoperative level of serum prealbumin may be useful for predicting long-term survival in patients with HCC after hepatectomy.
目的
确定血清前白蛋白水平是否与原发性肝细胞癌（HCC）患者肝切除术后的长期生存相关。
方法
回顾性分析了2007年8月至2010年8月期间连续526例行根治性肝切除术的HCC患者。根据200或182mg/L的临界值，将患者分为血清前白蛋白正常或降低两组。
结果
多因素分析确定术前血清前白蛋白水平是长期生存的独立预后因素（P<0.05）：基于任一临界值，血清前白蛋白水平正常者的生存率显著高于降低者。在基于肝硬化程度、甲胎蛋白水平和巴塞罗那临床肝癌分期的亚组分析中观察到类似结果。
结论
术前血清前白蛋白水平可能有助于预测HCC患者肝切除术后的长期生存。
Zotero 插件