Redox Biology Laboratory, Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Antioxid Redox Signal. 2019 Oct 20;31(12):858-873. doi: 10.1089/ars.2018.7712. Epub 2019 Mar 4.
Redox homeostasis is finely tuned and governed by distinct intracellular mechanisms. The dysregulation of this either by external or internal events is a fundamental pathophysiologic base for many pulmonary diseases. Based on recent discoveries, it is increasingly clear that cellular redox state and oxidation of signaling molecules are critical modulators of lung disease and represent a final common pathway that leads to poor respiratory outcomes. Based on the wide variety of stimuli that alter specific redox signaling pathways, improved understanding of the disease and patient-specific alterations are needed for the development of therapeutic targets. For the full comprehension of redox signaling in pulmonary disease, it is essential to recognize the role of reactive oxygen intermediates in modulating biological responses. This review summarizes current knowledge of redox signaling in pulmonary development and pulmonary vascular disease.
氧化还原平衡是由独特的细胞内机制精细调节和控制的。这种平衡无论是由外部还是内部事件引起的失调，都是许多肺部疾病的基本病理生理基础。基于最近的发现，越来越清楚的是，细胞内氧化还原状态和信号分子的氧化是肺部疾病的关键调节剂，代表了导致呼吸不良结局的共同途径。基于改变特定氧化还原信号通路的各种刺激，需要更好地了解疾病和患者特定的改变，以开发治疗靶点。为了全面理解肺部疾病中的氧化还原信号，必须认识到活性氧中间体在调节生物反应中的作用。这篇综述总结了氧化还原信号在肺发育和肺血管疾病中的最新知识。
