Brain S D, Tippins J R, Williams T J
Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middx.
Br J Pharmacol. 1988 Dec;95(4):1005-7. doi: 10.1111/j.1476-5381.1988.tb11731.x.
Endothelin is a recently discovered peptide produced by endothelial cells. It has been shown to have potent constrictor effects on major arteries in vitro and to raise rat blood pressure in vivo. The present experiments show that endothelin has a potent constrictor action on the microvasculature. Blood flow changes were measured by a xenon clearance technique in rabbit skin. Endothelin, when injected intradermally into rabbit skin, decreased local blood flow in a dose-dependent manner. Endothelin reduced basal skin blood flow and reversed the increased blood flow induced by a vasodilator. These results show that endothelin, administered extravascularly, has potent vasoconstrictor activity. This adds further support to the suggestion that endothelin may have an important role in the physiological control of blood flow and pressure.
内皮素是一种最近发现的由内皮细胞产生的肽。已表明它在体外对主要动脉有强大的收缩作用，并在体内使大鼠血压升高。目前的实验表明，内皮素对微脉管系统有强大的收缩作用。采用氙清除技术测量兔皮肤中的血流变化。当将内皮素皮内注射到兔皮肤中时，它以剂量依赖的方式降低局部血流。内皮素降低了基础皮肤血流，并逆转了由血管扩张剂诱导的血流增加。这些结果表明，血管外给予内皮素具有强大的血管收缩活性。这进一步支持了内皮素可能在血流和血压的生理控制中起重要作用的观点。
