内皮素可引起强烈的微血管收缩。
Endothelin induces potent microvascular constriction.
作者信息
Brain S D, Tippins J R, Williams T J
机构信息
Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middx.
出版信息
Br J Pharmacol. 1988 Dec;95(4):1005-7. doi: 10.1111/j.1476-5381.1988.tb11731.x.
Abstract
Endothelin is a recently discovered peptide produced by endothelial cells. It has been shown to have potent constrictor effects on major arteries in vitro and to raise rat blood pressure in vivo. The present experiments show that endothelin has a potent constrictor action on the microvasculature. Blood flow changes were measured by a xenon clearance technique in rabbit skin. Endothelin, when injected intradermally into rabbit skin, decreased local blood flow in a dose-dependent manner. Endothelin reduced basal skin blood flow and reversed the increased blood flow induced by a vasodilator. These results show that endothelin, administered extravascularly, has potent vasoconstrictor activity. This adds further support to the suggestion that endothelin may have an important role in the physiological control of blood flow and pressure.
摘要
内皮素是一种最近发现的由内皮细胞产生的肽。已表明它在体外对主要动脉有强大的收缩作用，并在体内使大鼠血压升高。目前的实验表明，内皮素对微脉管系统有强大的收缩作用。采用氙清除技术测量兔皮肤中的血流变化。当将内皮素皮内注射到兔皮肤中时，它以剂量依赖的方式降低局部血流。内皮素降低了基础皮肤血流，并逆转了由血管扩张剂诱导的血流增加。这些结果表明，血管外给予内皮素具有强大的血管收缩活性。这进一步支持了内皮素可能在血流和血压的生理控制中起重要作用的观点。
相似文献
1
Endothelin induces potent microvascular constriction.内皮素可引起强烈的微血管收缩。
Br J Pharmacol. 1988 Dec;95(4):1005-7. doi: 10.1111/j.1476-5381.1988.tb11731.x.
2
Mechanisms of endothelin-induced macromolecular leakage in microvascular beds of rat mesentery.内皮素诱导大鼠肠系膜微血管床大分子渗漏的机制。
Eur J Pharmacol. 1993 Nov 30;250(1):85-94. doi: 10.1016/0014-2999(93)90624-q.
3
Endothelium-dependent vascular activities of endothelin-like peptides in the isolated superior mesenteric arterial bed of the rat.内皮素样肽在大鼠离体肠系膜上动脉床中的内皮依赖性血管活性
Br J Pharmacol. 1990 Sep;101(1):81-8. doi: 10.1111/j.1476-5381.1990.tb12093.x.
4
Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1.大内皮素-1和大内皮素-3是微脉管系统中的血管收缩剂：大内皮素-1存在局部磷酰胺敏感转化的证据。
Eur J Pharmacol. 1993 Mar 23;233(2-3):243-50. doi: 10.1016/0014-2999(93)90056-n.
5
Endothelin-1: demonstration of potent effects on the microcirculation of humans and other species.内皮素-1：对人类和其他物种微循环的强效作用证明。
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S147-9; discussion S150.
6
Responses to endothelins in the rat cutaneous microvasculature: a modulatory role of locally-produced nitric oxide.大鼠皮肤微血管对内皮素的反应：局部产生的一氧化氮的调节作用。
Br J Pharmacol. 1992 Jul;106(3):733-8. doi: 10.1111/j.1476-5381.1992.tb14402.x.
7
Endothelin-induced vasoconstriction of small resistance vessels in the microcirculation of the rat cremaster muscle.内皮素诱导大鼠提睾肌微循环中小阻力血管的血管收缩。
Microvasc Res. 1990 Sep;40(2):191-8. doi: 10.1016/0026-2862(90)90018-m.
8
Endothelin is a potent long-lasting vasoconstrictor in men.内皮素对男性而言是一种强效且持久的血管收缩剂。
Am J Physiol. 1989 Dec;257(6 Pt 2):H2033-5. doi: 10.1152/ajpheart.1989.257.6.H2033.
9
Microvascular effects of endothelin in the rabbit tenuissimus muscle and hamster cheek pouch.内皮素对兔缝匠肌和仓鼠颊囊的微血管效应
Microvasc Res. 1989 Jan;37(1):115-8. doi: 10.1016/0026-2862(89)90076-9.
10
Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells.内皮素参与人体血管张力的调节。强大的血管收缩作用及在内皮细胞中的存在。
Circulation. 1990 Jun;81(6):1874-80. doi: 10.1161/01.cir.81.6.1874.
引用本文的文献
1
Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.β-淀粉样蛋白降解还是脑灌注？多功能酶的不同作用
Front Aging Neurosci. 2014 Sep 11;6:238. doi: 10.3389/fnagi.2014.00238. eCollection 2014.
2
Changes in left ventricular ejection fraction and coronary flow reserve after coronary microembolization.冠状动脉微栓塞后左心室射血分数和冠状动脉血流储备的变化。
Arch Med Sci. 2012 Feb 29;8(1):63-9. doi: 10.5114/aoms.2012.27283.
3
Effect of the endothelin receptor antagonist tezosentan on alpha-naphthylthiourea-induced lung injury in rats.内皮素受体拮抗剂替扎尼定对萘基硫脲诱导的大鼠肺损伤的影响。
Kaohsiung J Med Sci. 2012 Feb;28(2):72-8. doi: 10.1016/j.kjms.2011.10.019. Epub 2012 Jan 14.
4
The vasoactive potential of kisspeptin-10 in the peripheral vasculature.kisspeptin-10 在周围血管系统中的血管活性潜能。
PLoS One. 2011 Feb 9;6(2):e14671. doi: 10.1371/journal.pone.0014671.
5
Capillary dimension measured by computer-based digitalized image correlated with plasma endothelin-1 levels in patients with systemic sclerosis.基于计算机的数字化图像测量的毛细血管尺寸与系统性硬化症患者的血浆内皮素-1水平相关。
Clin Rheumatol. 2010 Mar;29(3):247-54. doi: 10.1007/s10067-009-1288-7. Epub 2009 Dec 31.
6
Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.内皮素-1在大鼠背部多毛皮肤中诱导的局部抗伤害感受作用。
J Pain. 2009 Jul;10(7):702-14. doi: 10.1016/j.jpain.2008.12.005.
7
Endothelin receptors and pain.内皮素受体与疼痛。
J Pain. 2009 Jan;10(1):4-28. doi: 10.1016/j.jpain.2008.09.009.
8
Digital vascular responses and serum endothelin-1 concentrations in primary and secondary Raynaud's phenomenon.原发性和继发性雷诺现象中的数字血管反应及血清内皮素-1浓度
Ann Rheum Dis. 2000 Nov;59(11):870-4. doi: 10.1136/ard.59.11.870.
9
Evidence for ETA and ETB receptors in rat skin and an investigation of their function in the cutaneous microvasculature.大鼠皮肤中ETA和ETB受体的证据及其在皮肤微血管系统中功能的研究。
Br J Pharmacol. 1995 Jul;115(5):840-4. doi: 10.1111/j.1476-5381.1995.tb15009.x.
10
Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors.内皮素-1通过激活ETA受体增强微血管通透性。
Br J Pharmacol. 1993 Jul;109(3):880-6. doi: 10.1111/j.1476-5381.1993.tb13657.x.
本文引用的文献
1
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.内皮细胞在乙酰胆碱介导的动脉平滑肌舒张中所起的不可或缺的作用。
Nature. 1980 Nov 27;288(5789):373-6. doi: 10.1038/288373a0.
2
Calcitonin gene-related peptide is a potent vasodilator.降钙素基因相关肽是一种强效血管舒张剂。
Nature. 1985;313(5997):54-6. doi: 10.1038/313054a0.
3
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.一种由血管内皮细胞产生的新型强效血管收缩肽。
Nature. 1988 Mar 31;332(6163):411-5. doi: 10.1038/332411a0.
4
Potent vasodilator activity of calcitonin gene-related peptide in human skin.降钙素基因相关肽在人体皮肤中的强效血管舒张活性。
J Invest Dermatol. 1986 Oct;87(4):533-6. doi: 10.1111/1523-1747.ep12455620.
5
6
Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.前列腺素E2、前列腺素I2与炎症的血管变化
Br J Pharmacol. 1979 Mar;65(3):517-24. doi: 10.1111/j.1476-5381.1979.tb07860.x.
Zotero 插件