Brain S D, Crossman D C, Buckley T L, Williams T J
Section of Vascular Biology, MRC Clinical Research Centre, Middlesex, London, England.
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S147-9; discussion S150.
The effect of endothelin-1 (ET-1) on microvessels was investigated by use of intravital microscopy and by measuring microvascular blood flow changes. ET-1 caused a selective constriction of arterioles in the hamster cheek pouch, without affecting venules. A decrease in blood flow was observed at the site of intradermal injection of ET-1 in rabbit and human skin. ET-1, as a consequence of its vasoconstrictor activity, acted in an anti-inflammatory manner to inhibit edema formation and neutrophil accumulation induced by chemotactic agents in rabbit skin. In human skin, a flare, due to increased blood flow, spread for several centimeters around a central constricted area. The flare, the result of an axon reflex, reveals an alternative mechanism through which ET-1 can act to modulate vascular tone.
通过活体显微镜检查并测量微血管血流变化，研究了内皮素-1（ET-1）对微血管的影响。ET-1可使仓鼠颊囊中的小动脉发生选择性收缩，而对小静脉无影响。在兔和人皮肤的皮内注射ET-1部位观察到血流减少。ET-1由于其血管收缩活性，以抗炎方式发挥作用，抑制趋化剂在兔皮肤中诱导的水肿形成和中性粒细胞聚集。在人皮肤中，由于血流增加导致的红晕在中央收缩区域周围扩散数厘米。这种红晕是轴突反射的结果，揭示了ET-1调节血管张力的另一种机制。
