内皮素衍生肽诱导大鼠胃损伤
Induction of rat gastric damage by the endothelium-derived peptide, endothelin.
作者信息
Whittle B J, Esplugues J V
机构信息
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
出版信息
Br J Pharmacol. 1988 Dec;95(4):1011-3. doi: 10.1111/j.1476-5381.1988.tb11733.x.
Abstract
The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.
摘要
内源性血管收缩肽内皮素对大鼠胃黏膜完整性的影响已得到研究。以皮摩尔剂量局部动脉内输注内皮素，可剂量依赖性地诱导胃黏膜出血和坏死性损伤。阿托品、西咪替丁、肾上腺素能受体拮抗剂、吲哚美辛或5-脂氧合酶抑制剂BW A4C均不能预防这种损伤。这些结果表明内皮素在胃损伤和溃疡发病机制中可能具有促溃疡形成的作用。
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本文引用的文献
1
Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa.血栓素A2引起的血管收缩会导致胃黏膜溃疡。
Nature. 1981 Jul 30;292(5822):472-4. doi: 10.1038/292472a0.
2
Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat.局部动脉内注射血小板活化因子（PAF）诱导大鼠胃黏膜损伤。
Br J Pharmacol. 1988 Jan;93(1):222-8. doi: 10.1111/j.1476-5381.1988.tb11425.x.
3
Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa.血栓素类似物U-46619经动脉内给药可导致大鼠胃黏膜损伤。
Prostaglandins. 1988 Feb;35(2):137-48. doi: 10.1016/0090-6980(88)90082-2.
4
Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.新型乙酰氧肟酸对花生四烯酸5-脂氧合酶的选择性抑制：体外和体内生化评估
Br J Pharmacol. 1988 Jun;94(2):528-39. doi: 10.1111/j.1476-5381.1988.tb11557.x.
5
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.一种由血管内皮细胞产生的新型强效血管收缩肽。
Nature. 1988 Mar 31;332(6163):411-5. doi: 10.1038/332411a0.
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