Whittle B J, Esplugues J V
Department of Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
Br J Pharmacol. 1988 Dec;95(4):1011-3. doi: 10.1111/j.1476-5381.1988.tb11733.x.
The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.
内源性血管收缩肽内皮素对大鼠胃黏膜完整性的影响已得到研究。以皮摩尔剂量局部动脉内输注内皮素，可剂量依赖性地诱导胃黏膜出血和坏死性损伤。阿托品、西咪替丁、肾上腺素能受体拮抗剂、吲哚美辛或5-脂氧合酶抑制剂BW A4C均不能预防这种损伤。这些结果表明内皮素在胃损伤和溃疡发病机制中可能具有促溃疡形成的作用。
