基于肿瘤细胞模板设计的协同微粒疫苗。
Coordination microparticle vaccines engineered from tumor cell templates.
机构信息
Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China.
出版信息
Chem Commun (Camb). 2019 Jan 31;55(11):1568-1571. doi: 10.1039/c8cc10004g.
A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.
一种用表没食子儿茶素没食子酸酯（EGCG）-Al（iii）配位层包裹单个肿瘤细胞的方法被开发出来，该方法可作为潜在的肿瘤疫苗。体外研究了微粒疫苗与树突状细胞（DC）的相互作用。通过肌动蛋白聚合和网格蛋白介导的内吞作用，这些粒径约为 10μm 的微粒被 DC 有效内化，摄取效率得到增强。
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