ω-3脂肪酸对难治性癫痫患者临床及辅助检查特征的影响：一项三盲随机临床试验
The effect of omega-3 fatty acids on clinical and paraclinical features of intractable epileptic patients: a triple blind randomized clinical trial.
作者信息
Omrani Shaghayegh, Taheri Mohammad, Omrani Mir Davood, Arsang-Jang Shahram, Ghafouri-Fard Soudeh
机构信息
Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Clin Transl Med. 2019 Jan 16;8(1):3. doi: 10.1186/s40169-019-0220-2.
Abstract
Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. In this triple blind randomized, placebo-controlled parallel group trial of omega-3 FA supplementation, 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) as well as placebo capsules were administered twice a day in 50 patients with refractory seizure during a 16-week period respectively. Seizure frequency and duration were reduced after completion of the treatment in the supplement group. The supplementation resulted in a significant decrease in TNF-α and IL-6 concentrations. Further studies are needed to compare different omega-3 FA compositions and determine the most effective dose and treatment duration as well as the long term benefits of this supplementation.
摘要
长链ω-3脂肪酸（ω-3 FAs）补充剂已被证明可通过提高癫痫发作阈值和减轻炎症反应，对癫痫患者产生有益影响。在这项ω-3 FA补充剂的三盲随机、安慰剂对照平行组试验中，180毫克二十碳五烯酸（EPA）和120毫克二十二碳六烯酸（DHA）以及安慰剂胶囊，分别在16周内每天两次给予50例难治性癫痫患者。补充剂组治疗结束后癫痫发作频率和持续时间降低。补充剂导致肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）浓度显著降低。需要进一步研究来比较不同的ω-3 FA成分，并确定最有效的剂量和治疗持续时间以及这种补充剂的长期益处。
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