Aygun Dursun, Dere Umit Akin, Yildiz Onur, Temel Yasin, Kocabicak Ersoy
Ondokuz Mayis University, Department of Neurology, Samsun, Turkey.
Turk Neurosurg. 2019;29(3):430-433. doi: 10.5137/1019-5149.JTN.24348-18.3.
To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson’s disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.
MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.
MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05).
MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.
研究微电极记录（MER）诱发的微损伤效应（MLE）对30例接受丘脑底核深部脑刺激的帕金森病（PD）患者运动症状的影响。
基于术前关状态与MER术中状态及测试刺激前震颤、强直和运动迟缓评分的差异，评估MER诱发的MLE。
与基线相比，MLE评分左侧（L）提高了21.7%，右侧（R）提高了13.6%（p<0.05）。震颤评分左侧提高了31.5%，右侧提高了14.2%（p<0.05）；强直评分左侧提高了17.3%，右侧提高了14.2%（p<0.05）；运动迟缓评分左侧提高了20.6%，右侧提高了11.5%（p<0.05）。MLE与使用的微电极数量之间无显著差异（p>0.05）。
MER诱发的MLE改善了运动症状，且与手术过程中使用的微电极数量无关。
