表征术中微电极记录对接受丘脑底核脑深部刺激的帕金森病患者运动症状的微损伤效应。
Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus.
作者信息
Aygun Dursun, Dere Umit Akin, Yildiz Onur, Temel Yasin, Kocabicak Ersoy
机构信息
Ondokuz Mayis University, Department of Neurology, Samsun, Turkey.
出版信息
Turk Neurosurg. 2019;29(3):430-433. doi: 10.5137/1019-5149.JTN.24348-18.3.
AIM
To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson’s disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.
MATERIAL AND METHODS
MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.
RESULTS
MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05).
CONCLUSION
MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.
目的
研究微电极记录（MER）诱发的微损伤效应（MLE）对30例接受丘脑底核深部脑刺激的帕金森病（PD）患者运动症状的影响。
材料与方法
基于术前关状态与MER术中状态及测试刺激前震颤、强直和运动迟缓评分的差异，评估MER诱发的MLE。
结果
与基线相比，MLE评分左侧（L）提高了21.7%，右侧（R）提高了13.6%（p<0.05）。震颤评分左侧提高了31.5%，右侧提高了14.2%（p<0.05）；强直评分左侧提高了17.3%，右侧提高了14.2%（p<0.05）；运动迟缓评分左侧提高了20.6%，右侧提高了11.5%（p<0.05）。MLE与使用的微电极数量之间无显著差异（p>0.05）。
结论
MER诱发的MLE改善了运动症状，且与手术过程中使用的微电极数量无关。
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