抵抗素：再评价。

Resistin: A reappraisal.

机构信息

DIMi, Department of Internal Medicine and medical specialties, Viale Benedetto XV, 6, 16132 University of Genoa, Genoa, Italy.

出版信息

Mech Ageing Dev. 2019 Mar;178:46-63. doi: 10.1016/j.mad.2019.01.004. Epub 2019 Jan 14.

DOI:10.1016/j.mad.2019.01.004

PMID:30650338

Abstract

From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging. Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases. Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.

摘要

从生物学角度来看，衰老可以被认为是生物体逐渐无法应对压力、维持体内平衡以及在成熟后生活中应对不利变化的能力下降。在衰老过程中，几种脂肪因子的表达会发生变化，并且对于一些变化，有人提出它们在慢性疾病和虚弱的发生中起作用。在脂肪因子中，抵抗素在最近的研究中被证明在衰老中起着关键作用。抵抗素是一种调节哺乳动物葡萄糖代谢的小分泌蛋白。高抵抗素水平可诱导胰岛素抵抗并发挥促炎作用。因此，抵抗素已被证明在各种代谢、炎症和自身免疫性疾病中发挥关键作用。本文综述了抵抗素作为衰老和与年龄相关疾病之间分子联系的作用，并讨论了这方面知识的临床意义。